UniProt Accession

 ANXA7_MOUSE; Q07076; Q3TT33 

Genbank Protein ID

 L13129; AK151438; AK161613; AK169199; CH466613 

Genbank Nucleotide ID

 AAA37238.1; BAE30401.1; BAE36492.1; BAE40974.1; EDL01512.1 

Protein Name

 Annexin A7 

Protein Synonyms/Alias

 Annexin VII; Annexin-7; Synexin 

Gene Name

 Anxa7 

Gene Synonyms/Alias

 Anx7 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
174	EILRKAMKGFGTDEQ	ubiquitination	[1]
203	QQIKAAFKTMYGKDL	acetylation	[2]
203	QQIKAAFKTMYGKDL	ubiquitination	[1]
208	AFKTMYGKDLIKDLK	acetylation	[2]
212	MYGKDLIKDLKSELS	ubiquitination	[1]
284	EFGRDLEKDIRSDTS	acetylation	[2]
284	EFGRDLEKDIRSDTS	ubiquitination	[1]
352	TRSFPQLKATMEAYS	ubiquitination	[1]
405	ERLYYSMKGAGTDDS	acetylation	[3]
405	ERLYYSMKGAGTDDS	ubiquitination	[1]
430	EIDLVQIKQMFTQMY	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. 

Sequence Annotation

 REPEAT 5 9 1.
 REPEAT 10 14 2.
 REPEAT 16 20 3.
 REPEAT 169 229 Annexin 1.
 REPEAT 241 301 Annexin 2.
 REPEAT 324 384 Annexin 3.
 REPEAT 400 460 Annexin 4.
 REGION 1 143 Repeat-rich region.
 REGION 5 20 3 X 5 AA tandem repeats of G-Y-P-P-X.
 MOD_RES 208 208 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Annexin; Calcium; Calcium/phospholipid-binding; Complete proteome; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 463 AA 

Protein Sequence

Gene Ontology

 GO:0042584; C:chromaffin granule membrane; IEA:Compara.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:Compara.
 GO:0005635; C:nuclear envelope; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0031982; C:vesicle; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
 GO:0008283; P:cell proliferation; IMP:MGI.
 GO:0006874; P:cellular calcium ion homeostasis; IMP:MGI.
 GO:0009992; P:cellular water homeostasis; IMP:MGI.
 GO:0007599; P:hemostasis; IMP:MGI.
 GO:0008360; P:regulation of cell shape; IMP:MGI.
 GO:0009651; P:response to salt stress; IMP:MGI.
 GO:0035176; P:social behavior; IEA:Compara. 

Interpro

 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR013286; AnnexinVII. 

Pfam

 PF00191; Annexin 

SMART

 SM00335; ANX 

PROSITE

 PS00223; ANNEXIN 

PRINTS

 PR00196; ANNEXIN.
 PR01871; ANNEXINVII.