UniProt Accession

 B2L10_HUMAN; Q9HD36; Q3SX80; Q52LQ9; Q8TCS9 

Genbank Protein ID

 AF285092; AF326964; AJ458330; AC023906; BC093826; BC093828; BC104442; BC104443 

Genbank Nucleotide ID

 AAG00503.1; AAK48715.1; CAD30221.1; AAH93826.1; AAH93828.1; AAI04443.1; AAI04444.1 

Protein Name

 Bcl-2-like protein 10 

Protein Synonyms/Alias

 Bcl2-L-10; Anti-apoptotic protein NrH; Apoptosis regulator Bcl-B 

Gene Name

 BCL2L10 

Gene Synonyms/Alias

 BCLB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
109	PLVTARWKKWGFQPR	ubiquitination	[1, 2]
110	LVTARWKKWGFQPRL	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. 

Sequence Annotation

 MOTIF 76 95 BH1.
 MOTIF 146 157 BH2.  

Keyword

 3D-structure; Apoptosis; Complete proteome; Membrane; Mitochondrion; Nucleus; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 194 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:HGNC.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; TAS:ProtInc.
 GO:0005739; C:mitochondrion; IDA:HGNC.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:ProtInc.
 GO:0007292; P:female gamete generation; TAS:ProtInc.
 GO:0043066; P:negative regulation of apoptotic process; IDA:HGNC.
 GO:0007283; P:spermatogenesis; TAS:ProtInc. 

Interpro

 IPR002475; Bcl2-like.
 IPR020717; Bcl2_BH1_motif_CS.
 IPR020726; Bcl2_BH2_motif_CS.
 IPR026312; BCL2L10.
 IPR026298; Blc2_fam. 

Pfam

 PF00452; Bcl-2 

SMART

  

PROSITE

 PS50062; BCL2_FAMILY
 PS01080; BH1
 PS01258; BH2 

PRINTS