CPLM-017730

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-017730

UniProt Accession

ATLA2_HUMAN; Q8NHH9; B7Z1X2; Q4ZG30; Q7Z630; Q8NHH8; Q9H5M7

Genbank Protein ID

AF449187; AF449176; AF449177; AF449178; AF449179; AF449180; AF449181; AF449182; AF449183; AF449184; AF449185; AF449186; AF449187; AF449176; AF449177; AF449178; AF449179; AF449180; AF449181; AF449182; AF449183; AF449184; AF449185; AF449186; AK294049; AK026946; AK225190; AC016995; BC053508

Genbank Nucleotide ID

AAM97341.1; AAM97341.1; AAM97341.1; AAM97341.1; AAM97341.1; AAM97341.1; AAM97341.1; AAM97341.1; AAM97341.1; AAM97341.1; AAM97341.1; AAM97341.1; AAM97342.1; AAM97342.1; AAM97342.1; AAM97342.1; AAM97342.1; AAM97342.1; AAM97342.1; AAM97342.1; AAM97342.1; AAM97342.1; AAM97342.1; AAM97342.1; BAH11658.1; BAB15598.1; AAX88950.1; AAH53508.1

Protein Name

Atlastin-2

Protein Synonyms/Alias

ADP-ribosylation factor-like protein 6-interacting protein 2; ARL-6-interacting protein 2; Aip-2

Gene Name

ATL2

Gene Synonyms/Alias

ARL6IP2

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
121	MLRYMYNKDSQSWIG	ubiquitination	[1]
361	EYFKAYIKIYQGEEL	ubiquitination	[1]
372	GEELPHPKSMLQATA	ubiquitination	[1]
461	ETYANFIKHNDGKNI	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.

Sequence Annotation

NP_BIND 101 108 GTP (Potential).
NP_BIND 173 177 GTP (Potential).
MOD_RES 24 24 Phosphoserine.

Keyword

Alternative splicing; Coiled coil; Complete proteome; Endoplasmic reticulum; GTP-binding; Hydrolase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

583 AA

Protein Sequence

MAEGDEAARG QQPHQGLWRR RRTSDPSAAV NHVSSTTSLG ENYEDDDLVN SDEVMKKPCP 60
VQIVLAHEDD HNFELDEEAL EQILLQEHIR DLNIVVVSVA GAFRKGKSFL LDFMLRYMYN 120
KDSQSWIGGN NEPLTGFTWR GGCERETTGI QVWNEVFVID RPNGTKVAVL LMDTQGAFDS 180
QSTIKDCATV FALSTMTSSV QVYNLSQNIQ EDDLQHLQLF TEYGRLAMEE IYQKPFQTLM 240
FLIRDWSYPY EHSYGLEGGK QFLEKRLQVK QNQHEELQNV RKHIHNCFSN LGCFLLPHPG 300
LKVATNPSFD GRLKDIDEDF KRELRNLVPL LLAPENLVEK EISGSKVTCR DLVEYFKAYI 360
KIYQGEELPH PKSMLQATAE ANNLAAVAGA RDTYCKSMEQ VCGGDKPYIA PSDLERKHLD 420
LKEVAIKQFR SVKKMGGDEF CRRYQDQLEA EIEETYANFI KHNDGKNIFY AARTPATLFA 480
VMFAMYIISG LTGFIGLNSI AVLCNLVMGL ALIFLCTWAY VKYSGEFREI GTVIDQIAET 540
LWEQVFSKLF EVTRRRMVHR ALSSAQRQRL SSNNNKKKN 579

Gene Ontology

GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral to membrane; IDA:UniProtKB.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0003924; F:GTPase activity; NAS:UniProtKB.
GO:0042802; F:identical protein binding; IDA:UniProtKB.
GO:0007029; P:endoplasmic reticulum organization; IMP:UniProtKB.
GO:0007030; P:Golgi organization; IMP:UniProtKB.
GO:0051260; P:protein homooligomerization; IDA:UniProtKB.

Interpro

IPR003191; Guanylate-bd_C.
IPR015894; Guanylate-bd_N.
IPR027417; P-loop_NTPase.

Pfam

PF02263; GBP
PF02841; GBP_C

SMART

PROSITE

PRINTS