UniProt Accession

 CPLX1_MOUSE; P63040; O09057; O09142; Q3UYB3; Q64276; Q91WJ3 

Genbank Protein ID

 D38614; AK134820; AK158166; AK159026; BC014803 

Genbank Nucleotide ID

 BAA07605.1; BAE22299.1; BAE34390.1; BAE34774.1; AAH14803.1 

Protein Name

 Complexin-1 

Protein Synonyms/Alias

 921-S; Complexin I; CPX I; Synaphin-2 

Gene Name

 Cplx1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
133	GPLQDMFKK******	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. 

Sequence Annotation

 REGION 48 70 Interaction with the SNARE complex (By  

Keyword

 Coiled coil; Complete proteome; Cytoplasm; Exocytosis; Neurotransmitter transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 134 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0030425; C:dendrite; ISO:MGI.
 GO:0043025; C:neuronal cell body; ISO:MGI.
 GO:0045202; C:synapse; ISO:MGI.
 GO:0070032; C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; ISO:MGI.
 GO:0005326; F:neurotransmitter transporter activity; IMP:UniProtKB.
 GO:0017075; F:syntaxin-1 binding; ISO:MGI.
 GO:0030073; P:insulin secretion; IMP:UniProtKB.
 GO:0016079; P:synaptic vesicle exocytosis; IMP:UniProtKB. 

Interpro

 IPR008849; Synaphin. 

Pfam

 PF05835; Synaphin 

SMART

  

PROSITE

  

PRINTS