CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016924
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Argininosuccinate lyase 
Protein Synonyms/Alias
 ASAL; Arginosuccinase 
Gene Name
 argH 
Gene Synonyms/Alias
 LA_2076 
Created Date
 July 27, 2013 
Organism
 Leptospira interrogans serogroup Icterohaemorrhagiae serovar La 
NCBI Taxa ID
 189518 
Lysine Modification
Position
Peptide
Type
References
33QSISFDHKLYKEDIQmethylation[1]
Reference
 [1] High-coverage proteome analysis reveals the first insight of protein modification systems in the pathogenic spirochete Leptospira interrogans.
 Cao XJ, Dai J, Xu H, Nie S, Chang X, Hu BY, Sheng QH, Wang LS, Ning ZB, Li YX, Guo XK, Zhao GP, Zeng R.
 Cell Res. 2010 Feb;20(2):197-210. [PMID: 19918266] 
Functional Description
  
Sequence Annotation
  
Keyword
 Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome; Cytoplasm; Lyase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 470 AA 
Protein Sequence
MTEKEKKLWG GRFQENASSI LERIGQSISF DHKLYKEDIQ GSIAHARMLK QIGILNSEEL 60
SKIEIALAQI KTELEEGKFE FKSELEDIHM HIEFRLTELI GETGKKLHTA RSRNDQVTQD 120
VRLYILNQGK EILKSIINLR SSLYQKAKQS LDVIIPGYTH LQIAQPIRAS QYLLSWFWAL 180
ERDQEFFRFA FKASEELALG SGAMAGVNYP TDREFLKKEL GLSKVSPNSM DGVSSRDHIL 240
EFLFACTQLM IHVSRICEDI ILYSSQEFGI LKLPDSLTTG SSIMPQKKNP DIAELIRGKS 300
GRVIGNLNHL LVMLKGLPST YNRDLQEDKL ALFDSIETVQ ISLEGIREMI EGWIWIPERA 360
EVSLKNGFAT ATDLADFLVN EKKIPFRTAH ELVGTLVGVC VKQKKTLFDL PESDRVSISK 420
YFVGKEYEDA VSLSLSADKK ISYGGTSKKR QEEQLKIALD SLKEAERLFL 470 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004056; F:argininosuccinate lyase activity; IEA:HAMAP.
 GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro. 
Interpro
 IPR009049; Argininosuccinate_lyase.
 IPR003031; D_crystallin.
 IPR024083; Fumarase/histidase_N.
 IPR000362; Fumarate_lyase.
 IPR020557; Fumarate_lyase_CS.
 IPR022761; Fumarate_lyase_N.
 IPR008948; L-Aspartase-like. 
Pfam
 PF00206; Lyase_1 
SMART
  
PROSITE
 PS00163; FUMARATE_LYASES 
PRINTS
 PR00145; ARGSUCLYASE.
 PR00149; FUMRATELYASE.