CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043803
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tripartite motif-containing protein 4 
Protein Synonyms/Alias
  
Gene Name
 TRIM4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
49NLVAKMKKVMHLQDVacetylation[1]
59HLQDVEVKNATQWKDubiquitination[2, 3]
123NQTIASLKKLILEVGubiquitination[2, 3, 4, 5]
124QTIASLKKLILEVGEubiquitination[5]
132LILEVGEKSQAPTLEubiquitination[5]
145LELLQNPKEVLTRSEubiquitination[2, 3, 5]
164NYSLEAVKVKTVCQIubiquitination[2, 3]
166SLEAVKVKTVCQIPLubiquitination[5]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 202 AA 
Protein Sequence
XDDQRPVCLV CRESQEHQTH AMAPIDEAFE SYREKLLKSQ RNLVAKMKKV MHLQDVEVKN 60
ATQWKDKIKS QRMRISTEFS KLHNFLVEEE DLFLQRLNKE EEETKKKLNE NTLKLNQTIA 120
SLKKLILEVG EKSQAPTLEL LQNPKEVLTR SEIQDVNYSL EAVKVKTVCQ IPLMKEMLKR 180
FQGIEKGDNV AEESDLSGRL HP 202 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR000315; Znf_B-box. 
Pfam
  
SMART
  
PROSITE
  
PRINTS