UniProt Accession

 AP3S1_MOUSE; Q9DCR2; O88670 

Genbank Protein ID

 AF084575; AK002565; BC012656 

Genbank Nucleotide ID

 AAC72819.1; BAB22191.1; AAH12656.1 

Protein Name

 AP-3 complex subunit sigma-1 

Protein Synonyms/Alias

 AP-3 complex subunit sigma-3A; Adapter-related protein complex 3 sigma-1 subunit; Sigma-3A-adaptin; Sigma3A-adaptin; Sigma-adaptin 3a 

Gene Name

 Ap3s1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
18	HGKPRLSKFYQPYSE	ubiquitination	[1]
166	ARAVSAVKNMNLPEI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasmic vesicle; Golgi apparatus; Membrane; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0030123; C:AP-3 adaptor complex; IEA:Compara.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005802; C:trans-Golgi network; TAS:MGI.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0008089; P:anterograde axon cargo transport; IMP:UniProtKB.
 GO:0048490; P:anterograde synaptic vesicle transport; IMP:UniProtKB.
 GO:0006886; P:intracellular protein transport; TAS:MGI. 

Interpro

 IPR016635; AP_complex_ssu.
 IPR022775; AP_mu_sigma_su.
 IPR000804; Clathrin_sm-chain_CS.
 IPR011012; Longin-like_dom. 

Pfam

 PF01217; Clat_adaptor_s 

SMART

  

PROSITE

 PS00989; CLAT_ADAPTOR_S 

PRINTS