| Tag | Content |
|---|
| CPLM ID | CPLM-007496 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcriptional activator HAC1 |
Protein Synonyms/Alias | |
Gene Name | HAC1 |
Gene Synonyms/Alias | ERN4; IRE15; IRE2; YFL031W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 38 | RAKTKEEKEQRRIER | acetylation | [1] |
|
Reference | [1] mChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases. Mitchell L, Huard S, Cotrut M, Pourhanifeh-Lemeri R, Steunou AL, Hamza A, Lambert JP, Zhou H, Ning Z, Basu A, Côté J, Figeys DA, Baetz K. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1641-50. [ PMID: 23572591] |
Functional Description | Transcriptional activator involved in the unfolded protein response (UPR) pathway. Recognizes and binds to the UPR element (UPRE) in the promoter of UPR-regulated genes such as KAR2, PDI1, EUG1 and FKB2. Increases the synthesis of endoplasmic reticulum-resident proteins required for protein folding as well as components of the secretory pathway. |
Sequence Annotation | DOMAIN 39 102 bZIP.
REGION 41 61 Basic motif (By similarity).
REGION 67 74 Leucine-zipper (By similarity). |
Keyword | Activator; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation; Unfolded protein response. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 238 AA |
Protein Sequence | MEMTDFELTS NSQSNLAIPT NFKSTLPPRK RAKTKEEKEQ RRIERILRNR RAAHQSREKK 60
RLHLQYLERK CSLLENLLNS VNLEKLADHE DALTCSHDAF VASLDEYRDF QSTRGASLDT 120
RASSHSSSDT FTPSPLNCTM EPATLSPKSM RDSASDQETS WELQMFKTEN VPESTTLPAV 180
DNNNLFDAVA SPLADPLCDD IAGNSLPFDN SIDLDNWRNP EAQSGLNSFE LNDFFITS 238 |
Gene Ontology | GO:0005634; C:nucleus; IDA:SGD. GO:0043565; F:sequence-specific DNA binding; IDA:SGD. GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IMP:SGD. GO:0010674; P:negative regulation of transcription from RNA polymerase II promoter during meiosis; IDA:SGD. GO:0006990; P:positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |