UniProt Accession

 PSMG2_HUMAN; Q969U7; B0YJB3; Q6IAH4 

Genbank Protein ID

 AF276707; EF445040; AK057005; CH471113; BC013356; CR457181; BR000237 

Genbank Nucleotide ID

 AAK69439.2; ACA06090.1; BAG51841.1; EAX01540.1; AAH13356.1; CAG33462.1; FAA00023.1 

Protein Name

 Proteasome assembly chaperone 2 

Protein Synonyms/Alias

 PAC-2; Hepatocellular carcinoma-susceptibility protein 3; Tumor necrosis factor superfamily member 5-induced protein 1 

Gene Name

 PSMG2 

Gene Synonyms/Alias

 HCCA3; PAC2; TNFSF5IP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
111	EKLLSWVKSSGCARV	ubiquitination	[1]
149	LLTPSMQKSVQNKIK	ubiquitination	[2, 3, 4, 5]
156	KSVQNKIKSLNWEEM	ubiquitination	[1, 4]
165	LNWEEMEKSRCIPEI	ubiquitination	[4]
188	IPGGGITKTLYDESC	ubiquitination	[3, 4]
246	TVSASRWKIPSSWRL	ubiquitination	[2, 5]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. 

Sequence Annotation

  

Keyword

 Chaperone; Complete proteome; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 264 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0007094; P:mitotic spindle assembly checkpoint; IEA:Compara.
 GO:0043248; P:proteasome assembly; IDA:UniProtKB.
 GO:0042981; P:regulation of apoptotic process; IEA:Compara. 

Interpro

 IPR019151; Proteasome_assmbl_chaperone_2.
 IPR016562; Proteasome_assmbl_chp_2_euk. 

Pfam

 PF09754; PAC2 

SMART

  

PROSITE

  

PRINTS