| Tag | Content |
|---|
| CPLM ID | CPLM-008815 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Monocarboxylate transporter 1 |
Protein Synonyms/Alias | MCT 1; Solute carrier family 16 member 1 |
Gene Name | Slc16a1 |
Gene Synonyms/Alias | Mct1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 219 | ESLQEAGKSDANTDL | ubiquitination | [1] | | 232 | DLIGGSPKGEKLSVF | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). |
Sequence Annotation | MOD_RES 210 210 Phosphoserine (By similarity).
MOD_RES 213 213 Phosphoserine.
MOD_RES 230 230 Phosphoserine (By similarity).
MOD_RES 459 459 Phosphothreonine (By similarity).
MOD_RES 460 460 Phosphoserine (By similarity).
MOD_RES 461 461 Phosphothreonine (By similarity).
MOD_RES 476 476 Phosphoserine (By similarity).
MOD_RES 492 492 Phosphoserine (By similarity). |
Keyword | Cell membrane; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 494 AA |
Protein Sequence | MPPAIGGPVG YTPPDGGWGW AVVVGAFISI GFSYAFPKSI TVFFKEIEII FSATTSEVSW 60
ISSIMLAVMY AGGPISSILV NKYGSRPVMI AGGCLSGCGL IAASFCNTVQ ELYFCIGVIG 120
GLGLAFNLNP ALTMIGKYFY KKRPLANGLA MAGSPVFLST LAPLNQAFFG IFGWRGSFLI 180
LGGLLLNCCV AGSLMRPIGP QQGKVEKLKS KESLQEAGKS DANTDLIGGS PKGEKLSVFQ 240
TVNKFLDLSL FTHRGFLLYL SGNVVMFFGL FTPLVFLSNY GKSKHFSSEK SAFLLSILAF 300
VDMVARPSMG LAANTRWIRP RVQYFFAASV VANGVCHLLA PLSTTYVGFC IYAGVFGFAF 360
GWLSSVLFET LMDLVGPQRF SSAVGLVTIV ECCPVLLGPP LLGRLNDMYG DYKYTYWACG 420
VILIIAGLYL FIGMGINYRL VAKEQKAEEK KRDGKEDETS TDVDEKPKKT MKETQSPAPL 480
QNSSGDPAEE ESPV 494 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005739; C:mitochondrion; IEA:Compara. GO:0005886; C:plasma membrane; IDA:RGD. GO:0097159; F:organic cyclic compound binding; IMP:RGD. GO:0042803; F:protein homodimerization activity; IDA:RGD. GO:0015355; F:secondary active monocarboxylate transmembrane transporter activity; IEA:InterPro. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD. GO:0035873; P:lactate transmembrane transport; IDA:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |