CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021344
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cdc42 effector protein 4 
Protein Synonyms/Alias
 Binder of Rho GTPases 4 
Gene Name
 CDC42EP4 
Gene Synonyms/Alias
 BORG4; CEP4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
75QPSSSSSKRSLLSRKubiquitination[1]
114RDSALFVKNAMSLPQubiquitination[1]
125SLPQLNEKEAAEKGTubiquitination[1]
146LSSSPVKKANDGEGGubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. 
Sequence Annotation
 DOMAIN 27 41 CRIB.
 MOD_RES 64 64 Phosphoserine.
 MOD_RES 109 109 Phosphoserine (By similarity).
 MOD_RES 118 118 Phosphoserine.
 MOD_RES 138 138 Phosphoserine.
 MOD_RES 140 140 Phosphoserine.
 MOD_RES 141 141 Phosphoserine (By similarity).
 MOD_RES 142 142 Phosphoserine.
 MOD_RES 174 174 Phosphoserine.
 MOD_RES 292 292 Phosphoserine.
 MOD_RES 295 295 Phosphoserine.  
Keyword
 Cell shape; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 356 AA 
Protein Sequence
MPILKQLVSS SVHSKRRSRA DLTAEMISAP LGDFRHTMHV GRAGDAFGDT SFLNSKAGEP 60
DGESLDEQPS SSSSKRSLLS RKFRGSKRSQ SVTRGEREQR DMLGSLRDSA LFVKNAMSLP 120
QLNEKEAAEK GTSKLPKSLS SSPVKKANDG EGGDEEAGTE EAVPRRNGAA GPHSPDPLLD 180
EQAFGDLTDL PVVPKATYGL KHAESIMSFH IDLGPSMLGD VLSIMDKEEW DPEEGEGGYH 240
GDEGAAGTIT QAPPYAVAAP PLARQEGKAG PDLPSLPSHA LEDEGWAAAA PSPGSARSMG 300
SHTTRDSSSL SSCTSGILEE RSPAFRGPDR ARAAVSRQPD KEFSFMDEEE EDEIRV 356 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:HPA.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-KW.
 GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
 GO:0017049; F:GTP-Rho binding; NAS:UniProtKB.
 GO:0031274; P:positive regulation of pseudopodium assembly; IDA:UniProtKB.
 GO:0008360; P:regulation of cell shape; IDA:UniProtKB.
 GO:0007266; P:Rho protein signal transduction; IEA:Compara. 
Interpro
 IPR000095; PAK_box_Rho-bd. 
Pfam
 PF00786; PBD 
SMART
  
PROSITE
 PS50108; CRIB 
PRINTS