CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026273
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Threonine--tRNA ligase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 TARS2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
37YHDFFLGKERCGTLVubiquitination[1, 2]
77HRGFSEVKTPTLFSTubiquitination[2]
130ITDTLALKPMNCPAHubiquitination[2]
245QVLKQALKEFGEPWDubiquitination[3]
297LRFDLQYKGQAGALEubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 443 AA 
Protein Sequence
MEHNPLPTSP ADQFNTGRYC SGPSTEYGFY HDFFLGKERC GTLVDLCQGP HLRHTGQIGG 60
LKLLSAEYAH RGFSEVKTPT LFSTKLWEQS GHWEHYQEDM FAVQPPGSDR PPSSQSDDST 120
RHITDTLALK PMNCPAHCLM FAHRPRSWRE LPLRLADFGA LHRAEASGGL GGLTRLRCFQ 180
QDDAHIFCTT DQLEAEIQSC LDFLRSVYAV LGFSFRLALS TRPSGFLGDP CLWDQAEQVL 240
KQALKEFGEP WDLNSGDGAF YGPKIDVHLH DALGRPHQCG TIQLDFQLPL RFDLQYKGQA 300
GALERPVLIH RAVLGSVERL LGVLAESCGG KWPLWLSPFQ VVVIPVGSEQ EEYAKEAQQS 360
LRAAGLVSDL DADSGLTLSR RIRRAQLAHY NFQFVVGQKE QSKRTVNIRT RDNRRLGEWD 420
LPEAVQRLVE LQNTRVPNAE EIF 443 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004829; F:threonine-tRNA ligase activity; IEA:InterPro.
 GO:0006435; P:threonyl-tRNA aminoacylation; IEA:InterPro. 
Interpro
 IPR002314; aa-tRNA-synt_IIb_cons-dom.
 IPR006195; aa-tRNA-synth_II.
 IPR004154; Anticodon-bd.
 IPR002320; Thr-tRNA-ligase_IIa.
 IPR012947; tRNA_SAD. 
Pfam
 PF03129; HGTP_anticodon
 PF00587; tRNA-synt_2b
 PF07973; tRNA_SAD 
SMART
  
PROSITE
 PS50862; AA_TRNA_LIGASE_II 
PRINTS
 PR01047; TRNASYNTHTHR.