UniProt Accession

 DCTP1_MOUSE; Q9QY93 

Genbank Protein ID

 AF110764; AK003643; AK010508; AK010606; BC004623 

Genbank Nucleotide ID

 AAF15970.1; BAB22909.1; BAB26992.1; BAB27056.1; AAH04623.1 

Protein Name

 dCTP pyrophosphatase 1 

Protein Synonyms/Alias

 Deoxycytidine-triphosphatase 1; dCTPase 1; RS21-C6; XTP3-transactivated gene A protein homolog 

Gene Name

 Dctpp1 

Gene Synonyms/Alias

 Tdrg-TL1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
140	LSRGSACKYTDLPRG	acetylation	[1, 2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non- canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases. 

Sequence Annotation

 REPEAT 29 75 EAR.
 REGION 47 51 Substrate binding.
 METAL 63 63 Magnesium (Probable).
 METAL 66 66 Magnesium (Probable).
 METAL 95 95 Magnesium (Probable).
 METAL 98 98 Magnesium (Probable).
 BINDING 38 38 Substrate.
 BINDING 73 73 Substrate.
 BINDING 102 102 Substrate.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 170 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0047840; F:dCTP diphosphatase activity; IEA:EC.
 GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
 GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IDA:UniProtKB.
 GO:0032556; F:pyrimidine deoxyribonucleotide binding; IDA:MGI.
 GO:0009143; P:nucleoside triphosphate catabolic process; IDA:UniProtKB.
 GO:0051289; P:protein homotetramerization; IDA:MGI. 

Interpro

 IPR009039; EAR.
 IPR004518; MazG_cat. 

Pfam

 PF03819; MazG 

SMART

  

PROSITE

 PS50912; EAR 

PRINTS