CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031969
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ral guanine nucleotide dissociation stimulator-like 1 
Protein Synonyms/Alias
 Ral guanine nucleotide dissociation stimulator-like 1, isoform CRA_d; cDNA FLJ50518, highly similar to Ral guanine nucleotide dissociation stimulator-like 1 
Gene Name
 RGL1 
Gene Synonyms/Alias
 hCG_2025089 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
17TQEVSKFKLSTKVESmethylation[1]
21SKFKLSTKVESTGHWmethylation[1]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Guanine-nucleotide releasing factor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 766 AA 
Protein Sequence
MEVKPVGEPT QEVSKFKLST KVESTGHWLV EDHVRIWEVL KTEEVEGDQL PPGHTVSQYE 60
TCKIRTIKAG TLEKLVENLL TAFGDNDFTY ISIFLSTYRG FASTKEVLEL LLDRYGNLTS 120
PNCEEDGSQS SSESKMVIRN AIASILRAWL DQCAEDFREP PHFPCLQKLL DYLTRMMPGS 180
DPERRAQNLL EQFQKQEVET DNGLPNTISF SLEEEEELEG GESAEFTCFS EDLVAEQLTY 240
MDAQLFKKVV PHHCLGCIWS RRDKKENKHL APTIRATISQ FNTLTKCVVS TILGGKELKT 300
QQRAKIIEKW INIAHECRLL KNFSSLRAIV SALQSNSIYR LKKTWAAVPR DRMLMFEELS 360
DIFSDHNNHL TSRELLMKEG TSKFANLDSS VKENQKRTQR RLQLQKDMGV MQGTVPYLGT 420
FLTDLTMLDT ALQDYIEGGL INFEKRRREF EVIAQIKLLQ SACNSYCMTP DQKFIQWFQR 480
QQLLTEEESY ALSCEIEAAA DASTTSPKPR KSMVKRLSLL FLGSDMITSP TPTKEQPKST 540
ASGSSGESMD SVSVSSCESN HSEAEEGSIT PMDTPDEPQK KLSESSSSCS SIHSMDTNSS 600
GMSSLINPLS SPPSCNNNPK IHKRSVSVTS ITSTVLPPVY NQQNEDTCII RISVEDNNGN 660
MYKSIMLTSQ DKTPAVIQRA MLKHNLDSDP AEEYELVQVI SEDKELVIPD SANVFYAMNS 720
QVNFDFILRK KNSMEEQVKL RSRTSLTLPR TAKRGCWSNR HSKITL 766 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR000159; Ras-assoc.
 IPR000651; Ras-like_Gua-exchang_fac_N.
 IPR019804; Ras_G-nucl-exch_fac_CS.
 IPR008937; Ras_GEF.
 IPR023578; Ras_GEF_dom.
 IPR001895; RasGRF_CDC25. 
Pfam
 PF00788; RA
 PF00617; RasGEF
 PF00618; RasGEF_N 
SMART
 SM00314; RA
 SM00147; RasGEF
 SM00229; RasGEFN 
PROSITE
 PS50200; RA
 PS00720; RASGEF
 PS50009; RASGEF_CAT
 PS50212; RASGEF_NTER 
PRINTS