CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028527
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dedicator of cytokinesis protein 7 
Protein Synonyms/Alias
  
Gene Name
 Dock7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
177QDEQDDLKRRSMSIDubiquitination[1]
922VRSIIGSKGLDRSNSacetylation[2]
1394KSKDMRAKLEEAILGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2128 AA 
Protein Sequence
MAERRAFAQK ISRTVAAEVR KQISGQYSGS PQLLKNLNIV GNISHHTTVP LTEAVDPVDL 60
EDYLVTHPLS GDSGPLRDLV EFPPDDIEVV YSPRDCRTLV SAVPEESEMD PHVRDCIRSY 120
TEDWAVVVRK YHKLGTGFNP NTLDKQKERQ KGLPRQVFES DEAPDGSSYQ DEQDDLKRRS 180
MSIDDTPRGS WACSIFDLKN SLPDALLPNL LDRTPNEEID HQNDDQRKSN RHKELFALHP 240
SPDEEEPIER LSVPDVPKEH FGQRLLVKCL SLKFEIEIEP IFASLALYDV KEKKKISENF 300
YFDLNSEQMK GLLRPHVPPA AITTLARSAI FSITYPSQDV FLVIKLEKVL QQGDIGECAE 360
PYMIFKEADA TKNKEKLEKL KSQADQFCQR LGKYRMPFAW TAIHLMNIVS SAGSLERDST 420
EVEISTGERK GSWSERRNSS LVGRRSLERT TSGDDACNLT SFRPATLTVA NFFKQEGDRL 480
SDEDLYKFLA DMRRPSSVLR RLRPITAQLK IDISPAPENP HYCLTPELLQ VKLYPDSRVR 540
PTREILEFPA RDVYVPNTTY RNLLYIYPQS LNFANRQGSA RNITVKVQFM YGEDPSNAMP 600
VIFGKSSCSE FSKEAYTAVV YHNRSPDFHE EIKVKLPATL TDHHHLLFTF YHVSCQQKQN 660
TPLETPVGYT WIPMLQNGRL KTGQFCLPVS LEKPPQAYSV LSPEVPLPGM KWVDNHKGVF 720
NVEVVAVSSI HTQDPYLDKF FALVNALDEH MFPVRIGDMR IMENNLESEL KSSISALNSS 780
QLEPVVRFLH LLLDKLILLV VRPPVIAGQI VNLGQASFEA MASIINRLHK NLEGNHDQHG 840
RNNLLASYIY YVFRLPNTYP NSPSPGPGGL GGSVHYATMA RSAVRPASLN LNRSRSLSNS 900
NPDISGTPTS PDDEVRSIIG SKGLDRSNSW VNTGPKAAPW GSNPSPSAES TQAMDRSCNR 960
MSSHTETSSF LQTLTGRLPT KKLFHEELAL QWVVCSGSVR ESALQQAWFF FELMVKSMVH 1020
HLYFNDKLDA PRKSRFPERF MDDIAALVST IAGDVVSRFQ KDTEMVERLN TSLAFFLNDL 1080
LSVMDRGFVF SLIKSCYKQV SAKLYSLPNP SVLVSLRLDF LRIICSHEHY VTLNLPCSLL 1140
TPPASPSPSV SSATSQSSGF STSVQDQKIA NMFELSLPFR QQHYLAGLVL TELALILDPD 1200
AEGLFGLHKK VINMVHNLLS THDSDPRYSD PQIKARVAML YLPLIGIIME TVPQLYDFTE 1260
SHNQRGRPIC IAPDDYDSES GSMISQTVAM AIAGTSVPQL TRPGSFLLTS TSGRQHTTFS 1320
AESSRSLLIC LLWVLKNADE TVLQKWFTDL SVLQLNRLLD LLYLCVSCFE YKGKKVFERM 1380
NSLTFKKSKD MRAKLEEAIL GSIGARQEMV RRSRGQLERS PSGSAFGSQE NLRWRKDMTH 1440
WRQNSEKLDK SRAEIEHEAL IDGNLATEAN LIILDTLEII VQTVSVTESK ESILGGVLKV 1500
LLQSMACNQS AVYLQHCFAT QRALVSKFPE LLFEEETEQC ADLCLRLLRH CSSSISTIRS 1560
HASASLYLLM RQNFEIGNNF ARVKMQVTMS LSSLVGTSQN FNEEFLRRSL KTILTYAEED 1620
LELRETTFPD QVQDLVFNLH MILSDTVKMK EHQEDPEMLI DLMYRIAKGY QTSPDLRLTW 1680
LQNMAGKHSE RSNHAEAAQC LVHSAALVAE YLSMLEDRKY LPVGCVTFQN ISSNVLEESA 1740
VSDDVVSPDE EGICSGKYFT ESGLVGLLEQ AAASFSMAGM YEAVNEVYKV LIPIHEANRD 1800
AKKLSTIHGK LQEAFSKIVH QDGKRMFGTY FRVGFYGTKF GDLDEQEFVY KEPAITKLAE 1860
ISHRLEGFYG ERFGEDVLEV IKDSNPVDKC KLDPNKAYIQ ITYVEPFFDT YEMKDRITYF 1920
DKNYNLRRFM YCTPFTLDGR AHGELHEQFK RKTILTTSHA FPYIKTRVNV THKEEIILTP 1980
IEVAIEDMQK KTQELAFATH QDPADPKMLQ MVLQGSVGTT VNQGPLEVAQ VFLSEIPGDP 2040
KLFRHHNKLR LCFKDFTKRC EDALRKNKSL IGPDQKEYQR ELERNYHRLK EALQPLINRK 2100
IPQLYKAVLP VTCHRDSFSR MSLRKMEL 2128 
Gene Ontology
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0043473; P:pigmentation; IMP:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027007; DHR-1_domain.
 IPR027357; DHR-2.
 IPR026791; DOCK.
 IPR010703; DOCK_C.
 IPR021816; DOCK_C/D_N.
 IPR026798; DOCK_C_fam. 
Pfam
 PF06920; Ded_cyto
 PF14429; DOCK-C2
 PF11878; DUF3398 
SMART
  
PROSITE
 PS51650; DHR_1
 PS51651; DHR_2 
PRINTS