UniProt Accession

 DLK1_HUMAN; P80370; P15803; Q96DW5 

Genbank Protein ID

 Z12172; U15979; U15981; X17544; AL132711; BC013197 

Genbank Nucleotide ID

 CAA78163.1; AAA75364.1; AAA75365.1; CAA35582.1; AAH13197.1 

Protein Name

 Protein delta homolog 1 

Protein Synonyms/Alias

 DLK-1; pG2; Fetal antigen 1; FA1 

Gene Name

 DLK1 

Gene Synonyms/Alias

 DLK 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
303	IDMTTFSKEAGDEEI	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May have a role in neuroendocrine differentiation. 

Sequence Annotation

 DOMAIN 24 55 EGF-like 1.
 DOMAIN 53 86 EGF-like 2.
 DOMAIN 88 125 EGF-like 3.
 DOMAIN 127 168 EGF-like 4.
 DOMAIN 170 206 EGF-like 5.
 DOMAIN 208 245 EGF-like 6.
 CARBOHYD 94 94 O-linked (GalNAc...).
 CARBOHYD 100 100 N-linked (GlcNAc...).
 CARBOHYD 143 143 O-linked (GalNAc...).
 CARBOHYD 163 163 O-linked (GalNAc...); partial.
 CARBOHYD 165 165 N-linked (GlcNAc...); partial; atypical.
 CARBOHYD 172 172 N-linked (GlcNAc...); partial; atypical.
 CARBOHYD 214 214 O-linked (GalNAc...).
 CARBOHYD 222 222 O-linked (GalNAc...); partial.
 CARBOHYD 251 251 O-linked (GalNAc...); partial.
 CARBOHYD 256 256 O-linked (GalNAc...).
 CARBOHYD 260 260 O-linked (GalNAc...); partial.
 DISULFID 26 37 By similarity.
 DISULFID 30 43 By similarity.
 DISULFID 45 54 By similarity.
 DISULFID 57 68 By similarity.
 DISULFID 63 74 By similarity.
 DISULFID 76 85 By similarity.
 DISULFID 92 103 By similarity.
 DISULFID 97 113 By similarity.
 DISULFID 115 124 By similarity.
 DISULFID 131 144 By similarity.
 DISULFID 138 156 By similarity.
 DISULFID 158 167 By similarity.
 DISULFID 174 185 By similarity.
 DISULFID 179 194 By similarity.
 DISULFID 196 205 By similarity.
 DISULFID 212 223 By similarity.
 DISULFID 217 233 By similarity.
 DISULFID 235 244 By similarity.  

Keyword

 Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 383 AA 

Protein Sequence

Gene Ontology

 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005615; C:extracellular space; TAS:ProtInc.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0048706; P:embryonic skeletal system development; IEA:Compara.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc.
 GO:0045746; P:negative regulation of Notch signaling pathway; IEA:Compara.
 GO:0007219; P:Notch signaling pathway; TAS:Reactome.
 GO:0009791; P:post-embryonic development; IEA:Compara. 

Interpro

 IPR000742; EG-like_dom.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site. 

Pfam

 PF00008; EGF
 PF12661; hEGF 

SMART

 SM00181; EGF 

PROSITE

 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3 

PRINTS