| Tag | Content |
|---|
| CPLM ID | CPLM-040038 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Non-lysosomal glucosylceramidase |
Protein Synonyms/Alias | NLGase |
Gene Name | GBA2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 97 | LAHEFTEKRKPFQAN | ubiquitination | [1] | | 134 | RKTHVEKKTPFIDMI | ubiquitination | [1] | | 592 | SGVMAPVKRRNVIPH | ubiquitination | [1] | | 767 | CAGQWFLKACGLGEG | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide (By similarity). |
Sequence Annotation | |
Keyword | Complete proteome; Endoplasmic reticulum; Glycosidase; Golgi apparatus; Hydrolase; Lipid metabolism; Membrane; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 933 AA |
Protein Sequence | MGTQDPGNMG TGVPASEQIS CAKEDPQVYC PEETGGTKDV QVTDCKSPED SRPPKETDCC 60
NPEDSGQLMV SYEGKAMGYQ VPPFGWRICL AHEFTEKRKP FQANNVSLSN MIKHIGMGLR 120
YLQWWYRKTH VEKKTPFIDM INSVPLRQIY GCPLGGIGGG TITRGWRGQF CRWQLNPGMY 180
QHRTVIADQP ICPLKFTVCL RREGQTVYQQ VLSLERPSVL RSWNWGLCGY FAFYHALYPR 240
AWTVYQLPGQ NVTLTCRQIT PILPHDYQDS SLPVGVFVWD VENEGDEALD VSIMFSMRNG 300
LGGGDDAPGG LWNEPFCLER SGETVRGLLL HHPTLPNPYT MAVAARVTAA TTVTHITAFD 360
PDSTGQQVWQ DLLQDGQLDS PTGQSTPTQK GVGIAGAVCV SSKLRPRGQC RLEFSLAWDM 420
PRIMFGAKGQ VHYRRYTRFF GQDGDAAPAL SHYALCRYAE WEERISAWQS PVLDDRSLPA 480
WYKSALFNEL YFLADGGTVW LEVLEDSLPE ELGRNMCHLR PTLRDYGRFG YLEGQEYRMY 540
NTYDVHFYAS FALIMLWPKL ELSLQYDMAL ATLREDLTRR RYLMSGVMAP VKRRNVIPHD 600
IGDPDDEPWL RVNAYLIHDT ADWKDLNLKF VLQVYRDYYL TGDQNFLKDM WPVCLAVMES 660
EMKFDKDHDG LIENGGYADQ TYDGWVTTGP SAYCGGLWLA AVAVMVQMAA LCGAQDIQDK 720
FSSILSRGQE AYERLLWNGR YYNYDSSSRP QSRSVMSDQC AGQWFLKACG LGEGDTEVFP 780
TQHVVRALQT IFELNVQAFA GGAMGAVNGM QPHGVPDKSS VQSDEVWVGV VYGLAATMIQ 840
EGLTWEGFQT AEGCYRTVWE RLGLAFQTPE AYCQQRVFRS LAYMRPLSIW AMQLALQQQQ 900
HKKASWPKVK QGTGLRTGPM FGPKEAMANL SPE 933 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:InterPro. GO:0004348; F:glucosylceramidase activity; IEA:EC. GO:0006680; P:glucosylceramide catabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |