CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038232
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Prr12 
Protein Synonyms/Alias
  
Gene Name
 Prr12 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
615GAGGYKGKGDGSELLacetylation[1]
751VHYGAGAKELGAFLQacetylation[2]
1061SPIFCSTKPKKLLKTacetylation[1]
1214GTRLEPLKPLKIKLSacetylation[3]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2035 AA 
Protein Sequence
MDRNYPSAGF GDPLGAGAGW SYERSAKASL VYGSSRTSHP ETDILHRQAY AAPHPLQSYA 60
TNHHPAGLSG LFDTGLHHAG SAGPDASVMN LISALESRGP QPGPSASSLL SQFRSPSWQT 120
AMHTPGPTEL FISGALPGSS TFPSSSALSA YQHPASFGSR PFPVPSSLSL QDPPFSPPAN 180
GLLSPHDVLH LKPSQAPTVP SSLGFERLAG GGVLGPAGLG PAQTPPYRPG PPDPPPPPRH 240
LPTQFNLLAS SSAATAAEPS SPQLYNFSGA APGPPPERAL PRQDTVIKHY QRPASAQPPP 300
PPPPAHSLQH YLSCGGSYPS MGHRASLACS PLGGGEPSPG AGEPSKGGPS GATAGAAGRA 360
TGPETAGGGA AGGGGGYRPI IQSPGYKTSK GGYGPATGGA TRPPPPRSTA TPKCQSLGGP 420
AAAYAAGKAS GAGGAGSQAY SPGQPQGLLG PQAYGQGFGG GQAQDLSKGP SYSGGPPQPP 480
SGPPPPGLAT CQSYSPDQLQ GQLYGVQSEP YPGPAAHSQG LPTASPSLSY STGHSPALSG 540
HGGGWGPSSL GGGGEASPSH IIRPLQSPPA TGRPPGVGSP GAPGKYLSSV LASAPFLAPP 600
GASSYAAGAG GYKGKGDGSE LLAGPGGSAA ERTEDEEFLI QHLLQAPSPP RTSGADGLVG 660
EDGPADAAKG LGGSGGAGGA PGTPYELAKE DPQRYHLQSV IRTSASLDEG ATAALELGLG 720
RMKDKKKGPE RGGETPEGLA TSVVHYGAGA KELGAFLQKS PPPPPPSAQA TQPAPHGLLL 780
EAGGPDLPMV LPPPPPQLLP SVLSHAPSPS PSAPKVGVHL LEPATRDGAP QPPPPPPPPM 840
PLQLEAHLRG HGLEPTAPSP RLRPEESLEP PGAMQELLGA LEPLPSGPGD PGVGPPNSEG 900
KDPAGAYRSP SPQGTKAPRF VPLTSICFPD SLLQDEERSF FPTMEEMFGG GAADDYGKAG 960
QTEDDGDPKT GAGPPPGPTA YDPYGPYCGG RASGTGPETP GLGLDHNKPP ELPSTVNAEP 1020
LGLIQSGPHQ SAPPPPPPPP PPPPVSEPKG GLTSPIFCST KPKKLLKTSS FHLLRRRDPP 1080
FQTPKKLYAQ EYEFEADEDK ADVPADIRLN PRRLPDLVSS CRSRPALSPL GDIDFCPPNP 1140
GPDGPRRRGR KPTKAKRDGP PRPRGRPRIR PLEGPAMAGP ASITTDGAKK PRGRGRGRGR 1200
KAEEMGGTRL EPLKPLKIKL SVPKAGEGLG APSNDVISGV DHNSLDSNLT REKIEAKIKE 1260
VEEKQPEMKS GFMASFLDFL KSGKRHPPLY QAGLTPPLSP PKSVPASVPT RGLQPPPPTV 1320
PTVPHPAPSG PFGLGGALEA AESEGLGLGC PSPCKRLDEE LKRNLETLPS FSSDEEDSVA 1380
KNRDLQESIS SAISALDDPP LTGPKDTSTP EEPPLDTGPT ASGPPPLPSL PSSNSSGTPE 1440
PPLLEEKPPP TPPPAPTPQP APPPPPPPPP VPALPSPTPL VTPVASSPPP PPPPPPPPPA 1500
LPSPPPPPPP APTTVPPVAP PEEPPAPSPE DPEPPDARPL HLAKKQETAA VCGETDEEAG 1560
ESGGEGIFRE RDEFVIRAED IPSLKLALQT GREPPPIWRV QKALLQKFTP EIKDGQRQFC 1620
ATSNYLGYFG DAKNRYQRLY VKFLENVNKK DYVRVCARKP WHRPPLPVRR SGQTKGPTPV 1680
GGNSAPPSKV QAPPPKPETP EKMTSEKPPE PAPEPAVPEP PAPEKPSPPR PVEKEKEKEK 1740
EKEKEKERVT RPLRSERATS GRQMRTDRSL ATGQSTTSRL PKARPSKVKA EPPPKKRKKW 1800
LKEAVGNASA GDGPGGSSSD SESSPGAPSE DERAVPGRLL KTRAMREMYR SYVEMLVSTA 1860
LDPDMIQALE DTHDELYLPP MRKIDGLLNE HKKKVLKRLS LSPALQDALH TFPQLQVEQT 1920
GEGSPEEGAV RLRPAGEPYN RKTLSKLKRS VVRAQEFKVE LEKSGYYTLY HSLHHYKYHT 1980
FLRCRDQTLA IEGGAEDLGQ EEVVQQCMRN QPWLEQLFDS FSDLLAQAQA HSRCG 2035 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro. 
Interpro
 IPR017956; AT_hook_DNA-bd_motif.
 IPR025451; DUF4211. 
Pfam
 PF13926; DUF4211 
SMART
 SM00384; AT_hook 
PROSITE
  
PRINTS