CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022697
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial dicarboxylate carrier 
Protein Synonyms/Alias
 Solute carrier family 25 member 10 
Gene Name
 Slc25a10 
Gene Synonyms/Alias
 Dic 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
40LQTQQEVKLRMTGMAacetylation[1]
158AREESLRKLFSGATMacetylation[2, 3]
158AREESLRKLFSGATMsuccinylation[3]
253LGPQAFFKGLFPAGIacetylation[2, 4]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199] 
Functional Description
 Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane. 
Sequence Annotation
 REPEAT 7 87 Solcar 1.
 REPEAT 100 187 Solcar 2.
 REPEAT 196 279 Solcar 3.  
Keyword
 Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 287 AA 
Protein Sequence
MAEARASRWY FGGLASCGAA CCTHPLDLLK VHLQTQQEVK LRMTGMALQV VRTDGFLALY 60
NGLSASLCRQ MTYSLTRFAI YETMRDYMTK DSQGPLPFYN KVLLGGISGL TGGFVGTPAD 120
LVNVRMQNDM KLPPSQRRNY SHALDGLYRV AREESLRKLF SGATMASSRG ALVTVGQLSC 180
YDQAKQLVLS TGYLSDNIFT HFVSSFIAGG CATFLCQPLD VLKTRLMNSK GEYQGVFHCA 240
METAKLGPQA FFKGLFPAGI RLIPHTVLTF MFLEQLRKHF GIKVPTT 287 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0015297; F:antiporter activity; IEA:Compara.
 GO:0015140; F:malate transmembrane transporter activity; IEA:Compara.
 GO:0015114; F:phosphate ion transmembrane transporter activity; IEA:Compara.
 GO:0015291; F:secondary active transmembrane transporter activity; IDA:MGI.
 GO:0015141; F:succinate transmembrane transporter activity; IEA:Compara.
 GO:0015116; F:sulfate transmembrane transporter activity; IEA:Compara.
 GO:0015117; F:thiosulfate transmembrane transporter activity; IEA:Compara.
 GO:0006839; P:mitochondrial transport; ISA:MGI.
 GO:0008272; P:sulfate transport; IEA:Compara.
 GO:0015709; P:thiosulfate transport; IEA:Compara. 
Interpro
 IPR002030; Mit_uncoupling.
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 
Pfam
 PF00153; Mito_carr 
SMART
  
PROSITE
 PS50920; SOLCAR 
PRINTS
 PR00784; MTUNCOUPLING.