| Tag | Content |
|---|
| CPLM ID | CPLM-024697 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription factor Sox-9-A |
Protein Synonyms/Alias | |
Gene Name | sox9-a |
Gene Synonyms/Alias | sox9 |
Created Date | July 27, 2013 |
Organism | Xenopus laevis (African clawed frog) |
NCBI Taxa ID | 8355 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 61 | PKGDQELKKETEDEK | sumoylation | [1] | | 253 | QPGKPDLKREGRPLQ | sumoylation | [1] | | 365 | SQQRTHIKTEQLSPS | sumoylation | [1] |
|
Reference | [1] SoxE factors function equivalently during neural crest and inner ear development and their activity is regulated by SUMOylation. Taylor KM, Labonne C. Dev Cell. 2005 Nov;9(5):593-603. [ PMID: 16256735] |
Functional Description | May be involved in chondrogenesis (cartilage development) during bone formation. Unlikely to play a role in sex determination but may function during testicular and ovarian differentiation (By similarity). Transcriptional activator. Acts early in neural crest formation, functioning redundantly with the other group E Sox factors sox8 and sox10 to induce neural crest progenitors. Induces sox10 expression downstream of wnt-signaling. Principally involved in development of the cranial neural crest, which is fated to form skeletal elements. Also required for otic placode specification during inner ear development. |
Sequence Annotation | DNA_BIND 105 173 HMG box.
CROSSLNK 61 61 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 365 365 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Activator; Chondrogenesis; Cytoplasm; Developmental protein; Differentiation; DNA-binding; Gonadal differentiation; Isopeptide bond; Nucleus; Transcription; Transcription regulation; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 477 AA |
Protein Sequence | MNLLDPFMKM TEEQDKCMSG APSPTMSDDS AGSPCPSGSG SDTENTRPQE NTFPKGDQEL 60
KKETEDEKFP VCIREAVSQV LKGYDWTLVP MPVRVNGSSK NKPHVKRPMN AFMVWAQAAR 120
RKLADQYPHL HNAELSKTLG KLWRLLNEGE KRPFVEEAER LRVQHKKDHP DYKYQPRRRK 180
SVKNGQTEQE DGAEQTHISP NAIFKALQAD SPHSSSSMSE VHSPGEHSGQ SQGPPTPPTT 240
PKTDIQPGKP DLKREGRPLQ ENGRQPPHID FRDVDIGELS SEVISTIETF DVNEFDQYLP 300
PNGHPGVGST QASYTGSYGI SSTPSATTGA GPAWMSKQQQ QQPQQHSLST LNSEQSQSQQ 360
RTHIKTEQLS PSHYSDQQQQ HSPQQLNYSS FNLQHYSSSY PTITRAQYDY TEHQGSSTYY 420
SHASGQNSGL YSTFSYMNPS QRPLYTPIAD TTGVPSIPQT HSPQHWEQPV YTQLTRP 477 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005634; C:nucleus; IDA:UniProtKB. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0051216; P:cartilage development; ISS:UniProtKB. GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW. GO:0014029; P:neural crest formation; IMP:UniProtKB. GO:0043049; P:otic placode formation; IMP:UniProtKB. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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