CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019907
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lambda-crystallin homolog 
Protein Synonyms/Alias
 L-gulonate 3-dehydrogenase; Gul3DH 
Gene Name
 Cryl1 
Gene Synonyms/Alias
 Cry 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
33ASGGFKVKLYDIEQQubiquitination[1]
54ENIRKEMKSLEQSGSubiquitination[1]
63LEQSGSLKGSLSAERubiquitination[1]
287VSEDMCMKVPDDPEHubiquitination[1]
308WRDDCLMKLSILKYQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 NP_BIND 16 17 NAD (By similarity).
 BINDING 36 36 NAD (By similarity).
 BINDING 97 97 NAD (By similarity).
 BINDING 102 102 NAD (By similarity).  
Keyword
 Complete proteome; Cytoplasm; NAD; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 319 AA 
Protein Sequence
MASPAAGGVV IVGSGLIGRS WAMLFASGGF KVKLYDIEQQ QITDALENIR KEMKSLEQSG 60
SLKGSLSAER QLSLISGCGN LAEAVEGAVH IQECVPENLE LKKKIFAQLD RIVDDRVILS 120
SSSSCLLPSK LFSGLAHVKQ CIVAHPVNPP YYVPLVELVP HPETAPATMD RTYALMKKIG 180
QSPVRVLKEI DGFVLNRLQY AVISEAWRLV EEEIVSPSDL DLVMSDGLGM RYAFIGPLET 240
MHLNAEGVIS YCERYSEGMK HVLSTFGPVP EFSGATVERV SEDMCMKVPD DPEHLAARRQ 300
WRDDCLMKLS ILKYQMQPK 319 
Gene Ontology
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
 GO:0050104; F:L-gulonate 3-dehydrogenase activity; ISS:UniProtKB.
 GO:0070403; F:NAD+ binding; ISS:UniProtKB.
 GO:0006631; P:fatty acid metabolic process; IEA:InterPro. 
Interpro
 IPR022694; 3-OHacyl-CoA_DH.
 IPR006180; 3-OHacyl-CoA_DH_CS.
 IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
 IPR006108; 3HC_DH_C.
 IPR008927; 6-PGluconate_DH_C-like.
 IPR013328; DH_multihelical.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00725; 3HCDH
 PF02737; 3HCDH_N 
SMART
  
PROSITE
 PS00067; 3HCDH 
PRINTS