CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007216
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 9 
Protein Synonyms/Alias
 Deubiquitinating enzyme 9; Ubiquitin thioesterase 9; Ubiquitin-specific-processing protease 9 
Gene Name
 UBP9 
Gene Synonyms/Alias
 YER098W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
45SGDPSIAKSPSAKSSubiquitination[1]
356VNNSNNNKENTFPTSubiquitination[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 
Functional Description
  
Sequence Annotation
 ACT_SITE 143 143 Nucleophile (By similarity).
 ACT_SITE 618 618 Proton acceptor (By similarity).  
Keyword
 Complete proteome; Hydrolase; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 754 AA 
Protein Sequence
MIKRWLSVNR KKSHPEKNTQ GNDEINRKAT SLKKTKGSGD PSIAKSPSAK SSTSSIPSNL 60
ASHERRSKFS SQTDNLAGNK HYHEHYHNMA STSDEREYDS STTYEDRAFD TESSILFTTI 120
TDLMPYGDGS NKVFGYENFG NTCYCNSVLQ CLYNIPEFRC NVLRYPERVA AVNRIRKSDL 180
KGSKIRVFTN ESFETSTNSG NSNTGYQSND NEDAHNHHHL QQSDQDNSSS STQEKQNNFE 240
RKRNSFMGFG KDKSNYKDSA KKDDNNEMER PQPVHTVVMA SDTLTEKLHE GCKKIIVGRP 300
LLKQSDSLSK ASTTDCQANS HCQCDSQGSR ITSVDDDVLV NPESCNDAVN NSNNNKENTF 360
PTSEQRKKAA LIRGPVLNVD HLLYPTEEAT LYNGLKDIFE SITENLSLTG IVSPTEFVKI 420
LKKENVLFNT MMQQDAHEFL NFLLNDFSEY IQRNNPRMRF GPQKTDNSND NFITDLFKGT 480
LTNRIKCLTC DNITSRDEPF LDFPIEVQGD EETDIQKMLK SYHQREMLNG VNKFYCNKCY 540
GLQEAERMVG LKQLPHILSL HLKRFKYSEE QKSNIKLFNK ILYPLTLDVS STFNTSVYKK 600
YELSGVVIHM GSGPQHGHYV CICRNEKFGW LLYDDETVES IKEETVLQFT GHPGDQTTAY 660
VLFYKETQAD KTENQNENID TSSQDQMQTD NNIEQLIKCD DWLRDRKLRA AANIERKKTL 720
GNIPEVKTAE TKTPLNDKKR NKQKRKSRIL SFIK 754 
Gene Ontology
 GO:0005737; C:cytoplasm; IC:SGD.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0004843; F:ubiquitin-specific protease activity; TAS:SGD.
 GO:0016579; P:protein deubiquitination; TAS:SGD.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19. 
Pfam
 PF00443; UCH 
SMART
  
PROSITE
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS