UniProt Accession

 DCP1_YEAST; Q12517; D6W1S0 

Genbank Protein ID

 Z48239; Z74891; AY558431; BK006948 

Genbank Nucleotide ID

 CAA88278.1; CAA99170.1; AAS56757.1; DAA10636.1 

Protein Name

 mRNA-decapping enzyme subunit 1 

Protein Synonyms/Alias

  

Gene Name

 DCP1 

Gene Synonyms/Alias

 YOL149W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
20	TQLEFYRKALNFNVI	ubiquitination	[1]
119	SGNGNSYKSNDSLTY	ubiquitination	[1]
130	SLTYNCGKTLSGKDI	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body. DCP1 is activated by the DEAD-box helicase DHH1 and destabilizes the eIF-4F cap-binding complex from the mRNA. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; mRNA processing; Nonsense-mediated mRNA decay; Phosphoprotein; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 231 AA 

Protein Sequence

Gene Ontology

 GO:0000932; C:cytoplasmic mRNA processing body; IDA:SGD.
 GO:0008047; F:enzyme activator activity; IDA:SGD.
 GO:0003729; F:mRNA binding; IPI:SGD.
 GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IDA:SGD.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW. 

Interpro

 IPR010334; DCP1.
 IPR011993; PH_like_dom. 

Pfam

 PF06058; DCP1 

SMART

  

PROSITE

  

PRINTS