UniProt Accession

 E7EMS6_HUMAN; E7EMS6 

Genbank Protein ID

 AC000080; AC000090; AC005663 

Genbank Nucleotide ID

  

Protein Name

 Catechol O-methyltransferase 

Protein Synonyms/Alias

  

Gene Name

 COMT 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
177	QDIIPQLKKKYDVDT	ubiquitination	[1]
178	DIIPQLKKKYDVDTL	ubiquitination	[1, 2, 3]
179	IIPQLKKKYDVDTLD	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 223 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0016206; F:catechol O-methyltransferase activity; IEA:Compara.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0042420; P:dopamine catabolic process; IEA:Compara.
 GO:0008210; P:estrogen metabolic process; IEA:Compara.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0007612; P:learning; IEA:Compara.
 GO:0048609; P:multicellular organismal reproductive process; IEA:Compara.
 GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Compara.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0042135; P:neurotransmitter catabolic process; IEA:InterPro.
 GO:0050668; P:positive regulation of homocysteine metabolic process; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0048265; P:response to pain; IEA:Compara. 

Interpro

 IPR025782; Catechol_O-MeTrfase.
 IPR017128; Catechol_O-MeTrfase_euk.
 IPR002935; O-MeTrfase_3. 

Pfam

 PF01596; Methyltransf_3 

SMART

  

PROSITE

 PS51557; SAM_MT_CATECHOL 

PRINTS