CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038675
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tripartite motif-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 Trim2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
239STFDELQKTLNVRKSubiquitination[1]
261VNYGLKHKVLQSQLDubiquitination[1]
509VGTKGRNKGEFTNLQubiquitination[1]
591SIFSNDGKFKTKIGSubiquitination[1]
600KTKIGSGKLMGPKGVacetylation[2]
605SGKLMGPKGVSVDRNacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 770 AA 
Protein Sequence
MPRSGRYGTQ QRAGSRTAGP PCQWSRMASE GASIPSPVVR QIDKQFLICS ICLERYKNPK 60
VLPCLHTFCE RCLQNYIPAH SLTLSCPVCR QTSILPEKGV AALQNNFFIT NLMDVLQRTP 120
GSNGEDSSIL ETVTAVAAGK PLSCPNHDGN VMEFYCQSCE TAMCRECTEG EHAEHPTVPL 180
KDVVEQHKAS LQVQLDAVNK RLPEIDSALQ FISEIIHQLT NQKASIVDDI HSTFDELQKT 240
LNVRKSVLLM ELEVNYGLKH KVLQSQLDTL LQGQESIKSC SNFTAQALNH GTETEVLLVK 300
KQMSEKLNEL ADQDFPLHPR ENDQLDFIVE TEGLKKSIHN LGTILTTNAV ASETVATGEG 360
LRQTIIGQPM SVTITTKDKD GELCKTGNAY LTAELSTPDG SVADGEILDN KNGTYEFLYT 420
VQKEGDFTLS LRLYDQHIRG SPFKLKVIRS ADVSPTTEGV KRRVKSPGSG HVKQKAVKRP 480
ASMYSTGKRK ENPIEDDLIF RVGTKGRNKG EFTNLQGVAA STSGKILIAD SNNQCVQIFS 540
NDGQFKSRFG IRGRSPGQLQ RPTGVAVHPS GDIIIADYDN KWVSIFSNDG KFKTKIGSGK 600
LMGPKGVSVD RNGHIIVVDN KACCVFIFQP NGKIVTRFGS RGNGDRQFAG PHFAAVNSNN 660
EIIITDFHNH SVKVFNQEGE FMLKFGSNGE GNGQFNAPTG VAVDSNGNII VADWGNSRIQ 720
VFDGSGSFLS YINTSADPLY GPQGLALTSD GHVVVADSGN HCFKVYRYLQ 770 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR003649; Bbox_C.
 IPR001298; Filamin.
 IPR017868; Filamin/ABP280_repeat-like.
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR001258; NHL_repeat.
 IPR013017; NHL_repeat_subgr.
 IPR000315; Znf_B-box.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00630; Filamin
 PF01436; NHL
 PF00643; zf-B_box 
SMART
 SM00502; BBC
 SM00336; BBOX
 SM00557; IG_FLMN
 SM00184; RING 
PROSITE
 PS50194; FILAMIN_REPEAT
 PS51125; NHL
 PS50119; ZF_BBOX
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS