UniProt Accession

 CD82_HUMAN; P27701; D3DQN6; E9PC70; Q7Z2D4; Q7Z5N2 

Genbank Protein ID

 X53795; S48196; U20770; AY303776; U67274; U67268; U67269; U67270; U67271; U67272; U67273; CR542255; AC010768; CH471064; CH471064; BC000726; BC001821 

Genbank Nucleotide ID

 CAA37804.1; AAB23825.1; AAC50133.1; AAP76181.1; AAC51205.1; AAC51205.1; AAC51205.1; AAC51205.1; AAC51205.1; AAC51205.1; AAC51205.1; CAG47051.1; EAW68063.1; EAW68064.1; AAH00726.1; AAH01821.1 

Protein Name

 CD82 antigen 

Protein Synonyms/Alias

 C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1; Suppressor of tumorigenicity 6 protein; Tetraspanin-27; Tspan-27; CD82 

Gene Name

 CD82 

Gene Synonyms/Alias

 KAI1; SAR2; ST6; TSPAN27 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
114	YFNMGKLKQEMGGIV	ubiquitination	[1, 2]
190	DNSLSVRKGFCEAPG	ubiquitination	[2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. 

Sequence Annotation

 CARBOHYD 129 129 N-linked (GlcNAc...).
 CARBOHYD 157 157 N-linked (GlcNAc...) (Potential).
 CARBOHYD 198 198 N-linked (GlcNAc...).  

Keyword

 Alternative splicing; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 267 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc. 

Interpro

 IPR000301; Tetraspanin.
 IPR018499; Tetraspanin/Peripherin.
 IPR018503; Tetraspanin_CS.
 IPR008952; Tetraspanin_EC2. 

Pfam

 PF00335; Tetraspannin 

SMART

  

PROSITE

 PS00421; TM4_1 

PRINTS

 PR00259; TMFOUR.