UniProt Accession

 D3YWB4_MOUSE; D3YWB4 

Genbank Protein ID

 AC113029; AC122339 

Genbank Nucleotide ID

  

Protein Name

 Rab5 GDP/GTP exchange factor 

Protein Synonyms/Alias

  

Gene Name

 Rabgef1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
85	AQSLTFSKFEEKKTN	ubiquitination	[1]
103	RKVTTVKKFFSASSR	ubiquitination	[1]
171	FLEAMPYKRDLSIEE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 221 AA 

Protein Sequence

Gene Ontology

 GO:0031982; C:vesicle; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0050728; P:negative regulation of inflammatory response; IMP:MGI.
 GO:1900165; P:negative regulation of interleukin-6 secretion; IMP:MGI.
 GO:1900235; P:negative regulation of Kit signaling pathway; IMP:MGI.
 GO:0002686; P:negative regulation of leukocyte migration; IMP:MGI.
 GO:0043305; P:negative regulation of mast cell degranulation; IMP:MGI.
 GO:0001933; P:negative regulation of protein phosphorylation; IMP:MGI.
 GO:0046580; P:negative regulation of Ras protein signal transduction; IMP:MGI.
 GO:0048261; P:negative regulation of receptor-mediated endocytosis; IMP:MGI.
 GO:0060368; P:regulation of Fc receptor mediated stimulatory signaling pathway; IDA:MGI. 

Interpro

 IPR002653; Znf_A20. 

Pfam

 PF01754; zf-A20 

SMART

 SM00259; ZnF_A20 

PROSITE

 PS51036; ZF_A20 

PRINTS