UniProt Accession

 DDR1_MOUSE; Q03146 

Genbank Protein ID

 L57509; X57240 

Genbank Nucleotide ID

 AAB05209.1; CAA40516.1 

Protein Name

 Epithelial discoidin domain-containing receptor 1 

Protein Synonyms/Alias

 Epithelial discoidin domain receptor 1; CD167 antigen-like family member A; Cell adhesion kinase; Discoidin receptor tyrosine kinase; Protein-tyrosine kinase MPK-6; Tyrosine kinase DDR; Tyrosine-protein kinase CAK; CD167a 

Gene Name

 Ddr1 

Gene Synonyms/Alias

 Cak; Eddr1; Mpk6 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
661	ILRPDATKNARNDFL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (By similarity). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. 

Sequence Annotation

 DOMAIN 32 186 F5/8 type C.
 DOMAIN 608 903 Protein kinase.
 NP_BIND 614 622 ATP (By similarity).
 REGION 193 369 DS-like domain (By similarity).
 MOTIF 479 482 PPxY motif.
 ACT_SITE 764 764 Proton acceptor (By similarity).
 METAL 213 213 Calcium 1; via carbonyl oxygen (By
 METAL 232 232 Calcium 1 (By similarity).
 METAL 232 232 Calcium 2; via carbonyl oxygen (By
 METAL 235 235 Calcium 2 (By similarity).
 METAL 237 237 Calcium 2; via carbonyl oxygen (By
 METAL 255 255 Calcium 1; via carbonyl oxygen (By
 METAL 257 257 Calcium 1; via carbonyl oxygen (By
 METAL 362 362 Calcium 2; via carbonyl oxygen (By
 METAL 363 363 Calcium 2 (By similarity).
 BINDING 653 653 ATP (By similarity).
 MOD_RES 511 511 Phosphotyrosine; by autocatalysis (By
 MOD_RES 738 738 Phosphotyrosine; by autocatalysis (By
 MOD_RES 790 790 Phosphotyrosine; by autocatalysis (By
 MOD_RES 794 794 Phosphotyrosine; by autocatalysis (By
 MOD_RES 795 795 Phosphotyrosine; by autocatalysis (By
 CARBOHYD 213 213 N-linked (GlcNAc...) (Potential).
 CARBOHYD 262 262 N-linked (GlcNAc...) (Potential).
 CARBOHYD 372 372 N-linked (GlcNAc...) (Potential).
 CARBOHYD 392 392 N-linked (GlcNAc...) (Potential).
 DISULFID 32 186 By similarity.
 DISULFID 75 178 By similarity.
 DISULFID 305 350 By similarity.  

Keyword

 Alternative splicing; ATP-binding; Calcium; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Lactation; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Pregnancy; Receptor; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 911 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005518; F:collagen binding; IMP:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0038062; F:protein tyrosine kinase collagen receptor activity; ISS:UniProtKB.
 GO:0060444; P:branching involved in mammary gland duct morphogenesis; IMP:MGI.
 GO:0043583; P:ear development; IMP:MGI.
 GO:0007566; P:embryo implantation; IMP:MGI.
 GO:0007595; P:lactation; IEA:UniProtKB-KW.
 GO:0060749; P:mammary gland alveolus development; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:0038083; P:peptidyl-tyrosine autophosphorylation; ISS:UniProtKB.
 GO:0001558; P:regulation of cell growth; IMP:MGI.
 GO:0001952; P:regulation of cell-matrix adhesion; IMP:MGI.
 GO:0010715; P:regulation of extracellular matrix disassembly; IMP:UniProtKB.
 GO:0014909; P:smooth muscle cell migration; IMP:UniProtKB.
 GO:0061302; P:smooth muscle cell-matrix adhesion; IMP:UniProtKB.
 GO:0044319; P:wound healing, spreading of cells; IMP:UniProtKB. 

Interpro

 IPR000421; Coagulation_fac_5/8-C_type_dom.
 IPR008979; Galactose-bd-like.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR002011; Tyr_kinase_rcpt_2_CS. 

Pfam

 PF00754; F5_F8_type_C
 PF07714; Pkinase_Tyr 

SMART

 SM00231; FA58C
 SM00219; TyrKc 

PROSITE

 PS01285; FA58C_1
 PS01286; FA58C_2
 PS50022; FA58C_3
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00239; RECEPTOR_TYR_KIN_II 

PRINTS

 PR00109; TYRKINASE.