UniProt Accession

 SMD3_MOUSE; P62320; P43331; Q3TV81 

Genbank Protein ID

 AK005341; AK006692; AK019453; AK160321 

Genbank Nucleotide ID

 BAB23963.1; BAB24705.1; BAB31729.1; BAE35738.1 

Protein Name

 Small nuclear ribonucleoprotein Sm D3 

Protein Synonyms/Alias

 Sm-D3; snRNP core protein D3 

Gene Name

 Snrpd3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
8	MSIGVPIKVLHEAEG	acetylation	[1]
78	LILPDMLKNAPMLKS	acetylation	[2]
78	LILPDMLKNAPMLKS	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing (By similarity). Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. 

Sequence Annotation

 REPEAT 110 111 1.
 REPEAT 112 113 2.
 REPEAT 114 115 3.
 REPEAT 116 117 4.
 REPEAT 118 119 5.
 REGION 110 119 5 X 2 AA tandem repeats of [RM]-G.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 97 97 Omega-N-methylated arginine (By  

Keyword

 Acetylation; Complete proteome; Methylation; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 126 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005689; C:U12-type spliceosomal complex; IEA:Compara.
 GO:0005683; C:U7 snRNP; ISS:UniProtKB.
 GO:0071208; F:histone pre-mRNA DCP binding; IDA:UniProtKB.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR027141; LSm4/Sm_D1/D3.
 IPR010920; LSM_dom.
 IPR001163; Ribonucl_LSM.
 IPR006649; Ribonucl_LSM_euk/arc. 

Pfam

 PF01423; LSM 

SMART

 SM00651; Sm 

PROSITE

  

PRINTS