CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028806
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Scn3a 
Protein Synonyms/Alias
  
Gene Name
 Scn3a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
454QMLEQLKKQQEEAQAubiquitination[1]
1837FMASNPSKVSYEPITubiquitination[1]
1848EPITTTLKRKQEEVSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Sodium; Sodium channel; Sodium transport; Transmembrane; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1947 AA 
Protein Sequence
MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDIDDENKPK PNSDLEAGKN 60
LPFIYGDIPP EMVSEPLEDL DPYYVSKKTF VVLNKGKAIF RFSATSALYI LTPLNPVRKI 120
AIKILVHSLF SMLIMCTILT NCVFMTLSNP PDWTKNVEYT FTGIYTFESL IKILARGFCL 180
EDFTFLRDPW NWLDFSVIVM AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL 240
IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFEIN TTSYFNGTMD 300
SNGTFVNVTM STFNWKDYIA DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY ICVKAGRNPN 360
YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY MIFFVLVIFL GSFYLVNLIL 420
AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE QLKKQQEEAQ AVAAASAASR DFSGIGGLGE 480
LLESSSEASK LSSKSAKEWR NRRKKRRQRE HLEGNHRPEG DRFPKSESED SVKRRSFLFS 540
LDGNPLSGDK KLCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST 600
FEDSESRRDS LFVPHRPGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS SGRQRAMSIA 660
SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDSWLKV KHLVNLIVMD PFVDLAITIC 720
IVLNTLFMAM EHYPMTEQFS SVLTVGNLVF TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG 780
IIVSLSLMEL GLANVEGLSV LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL 840
AIIVFIFAVV GMQLFGKSYK ECVCKINEDC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW 900
DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN EMNNLQIAVG 960
RMQKGIDYVK NKIRECFRKA FFRKPKVIEI HEGNKIDSCM SNNTGVVEIS KELNYLKDGN 1020
GTTSGVGTGS SVEKYVIDEN DYMSFINNPS LTVTVPIAVG ESDFENLNTE EFSSESELEE 1080
SKEKLNATSS SEGSTVDVAP PREGEQAEIE PEEDLKPEAC FTEGCIKKFP FCQVSTEEGK 1140
GKIWWNLRKT CYSIVEHNWF ETFIVFMILL SSGALAFEDI YIEQRKTIKT MLEYADKVFT 1200
YIFILEMLLK WVAYGFQTYF TNAWCWLDFL IVDVSLVSLV ANALGYSELG AIKSLRTLRA 1260
LRPLRALSRF EGMRVVVNAL VGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKFYHCVNMT 1320
TGSMFDMSEV NNFSDCQALG KQARWKNVKV NFDNVGAGYL ALLQVATFKG WMDIMYAAVD 1380
SRDVKLQPVY EENLYMYLYF VIFIIFGSFF TLNLFIGVII DNFNQQKKKF GGQDIFMTEE 1440
QKKYYNAMKK LGSKKPQKPI PRPANKFQGM VFDFVTRQVF DISIMILICL NMVTMMVETD 1500
DQSKYMTLVL SRINLVFIVL FTGEFLLKLI SLRYYYFTIG WNIFDFVVVI LSIVGMFLAE 1560
LIEKYFVSPT LFRVIRLARI GRILRLIKGA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI 1620
YAIFGMSNFA YVKKEAGIDD MFNFETFGNS MICLFQITTS AGWDGLLAPI LNSAPPDCDP 1680
DAIHPGSSVK GDCGNPSVGI FFFVSYIIIS FLVVVNMYIA VILENFSVAT EESAEPLSED 1740
DFEMFYEVWE KFDPDATQFI EFCKLSDFAA ALDPPLLIAK PNKVQLIAMD LPMVSGDRIH 1800
CLDILFAFTK RVLGESGEMD ALRIQMEDRF MASNPSKVSY EPITTTLKRK QEEVSAAIIQ 1860
RNYRCYLLKQ RLKNISNTYD KETIKGRIVL PIKGDMVIDK LNGNSTPEKT DGSSSTTSPP 1920
SYDSVTKPDK EKFEKDKPEK ESKGKEV 1947 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
 GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
 GO:0035725; P:sodium ion transmembrane transport; IEA:GOC. 
Interpro
 IPR024583; DUF3451.
 IPR005821; Ion_trans_dom.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027359; K_channel_four-helix_dom.
 IPR001696; Na_channel_asu.
 IPR010526; Na_trans_assoc. 
Pfam
 PF11933; DUF3451
 PF00520; Ion_trans
 PF06512; Na_trans_assoc 
SMART
 SM00015; IQ 
PROSITE
  
PRINTS
 PR00170; NACHANNEL.