CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023949
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Host cell factor 2 
Protein Synonyms/Alias
 HCF-2; C2 factor 
Gene Name
 HCFC2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
338SGRDGYKKALNSQVCubiquitination[1]
347LNSQVCCKDLWYLDTubiquitination[1]
444KTEQPATKETSMKNKubiquitination[1]
788WLQGNNKKAPLN***acetylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 REPEAT 34 79 Kelch 1.
 REPEAT 83 130 Kelch 2.
 REPEAT 207 255 Kelch 3.
 REPEAT 257 303 Kelch 4.
 DOMAIN 357 442 Fibronectin type-III 1.
 DOMAIN 580 672 Fibronectin type-III 2.
 DOMAIN 678 782 Fibronectin type-III 3.  
Keyword
 Complete proteome; Cytoplasm; Kelch repeat; Nucleus; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 792 AA 
Protein Sequence
MAAPSLLNWR RVSSFTGPVP RARHGHRAVA IRELMIIFGG GNEGIADELH VYNTATNQWF 60
LPAVRGDIPP GCAAHGFVCD GTRILVFGGM VEYGRYSNEL YELQASRWLW KKVKPHPPPS 120
GLPPCPRLGH SFSLYGNKCY LFGGLANESE DSNNNVPRYL NDFYELELQH GSGVVGWSIP 180
VTKGVVPSPR ESHTAVIYCK KDSGSPKMYV FGGMCGARLD DLWQLDLETM SWSKPETKGT 240
VPLPRSLHTA SVIGNKMYIF GGWVPHKGEN TETSPHDCEW RCTSSFSYLN LDTTEWTTLV 300
SDSQEDKKNS RPRPRAGHCA VAIGTRLYFW SGRDGYKKAL NSQVCCKDLW YLDTEKPPAP 360
SQVQLIKATT NSFHVKWDEV STVEGYLLQL STDLPYQAAS SDSSAAPNMQ GVRMDPHRQG 420
SNNIVPNSIN DTINSTKTEQ PATKETSMKN KPDFKALTDS NAILYPSLAS NASNHNSHVV 480
DMLRKNEGPH TSANVGVLSS CLDVRTVIPE TSVSSTVSST QTMVTQQTIK TESSSTNGAV 540
VKDETSLTTF STKSEVDETY ALPATKISRV ETHATATPFS KETPSNPVAT VKAGERQWCD 600
VGIFKNNTAL VSQFYLLPKG KQSISKVGNA DVPDYSLLKK QDLVPGTGYR FRVAAINGCG 660
IGPFSKISEF KTCIPGFPGA PSAVRISKNV EGIHLSWEPP TSPSGNILEY SAYLAIRTAQ 720
IQDNPSQLVF MRIYCGLKTS CIVTAGQLAN AHIDYTSRPA IVFRISAKNE KGYGPATQVR 780
WLQGNNKKAP LN 792 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:ProtInc.
 GO:0003713; F:transcription coactivator activity; TAS:ProtInc.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0016032; P:viral reproduction; TAS:ProtInc. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR015916; Gal_Oxidase_b-propeller.
 IPR013783; Ig-like_fold.
 IPR015915; Kelch-typ_b-propeller. 
Pfam
  
SMART
 SM00060; FN3 
PROSITE
 PS50853; FN3 
PRINTS