Tag | Content |
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CPLM ID | CPLM-024158 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Peroxisomal 2,4-dienoyl-CoA reductase |
Protein Synonyms/Alias | 2,4-dienoyl-CoA reductase 2; DCR-AKL; pVI-AKL |
Gene Name | Decr2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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102 | AAVDQALKEFGKIDI | acetylation | [1] | 230 | PKASSKFKYLSSPIP | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19- docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. |
Sequence Annotation | NP_BIND 35 40 NADP (By similarity). NP_BIND 60 64 NADP (By similarity). NP_BIND 208 214 NADP (By similarity). REGION 126 128 Substrate binding (By similarity). MOTIF 290 292 Microbody targeting signal. BINDING 60 60 Substrate (By similarity). BINDING 86 86 NADP (By similarity). BINDING 88 88 Substrate (By similarity). BINDING 118 118 Substrate (By similarity). BINDING 182 182 NADP (By similarity). BINDING 219 219 Substrate (By similarity). MOD_RES 151 151 N6-acetyllysine (By similarity). MOD_RES 291 291 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Complete proteome; Fatty acid metabolism; Lipid metabolism; NADP; Oxidoreductase; Peroxisome; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 292 AA |
Protein Sequence | MTQQPPDVEE DDCLSEYHHL FCPDLLQDKV AFITGGGSGI GFRIAEIFMR HGCHTVIVSR 60 SLPRVSEAAK KLVAATGKRC LPLSMDVRVP PAVMAAVDQA LKEFGKIDIL INCAAGNFLC 120 PASALSFNAF KTVVDIDTLG TFNVSRVLYE KFFRDHGGVI VNITATLSMR GQVLQLHAGA 180 AKAAVDAMTR HLAVEWGPQN IRVNSLAPGA ISGTEGLRRL GGPKASSKFK YLSSPIPRLG 240 TKTEIAHSVL YLASPLASYV SGIVLVVDGG SWMTLPNDIG RLLEFESSSA KL 292 |
Gene Ontology | GO:0005778; C:peroxisomal membrane; IDA:UniProtKB. GO:0008670; F:2,4-dienoyl-CoA reductase (NADPH) activity; IDA:UniProtKB. GO:0019166; F:trans-2-enoyl-CoA reductase (NADPH) activity; IEA:Compara. GO:0006636; P:unsaturated fatty acid biosynthetic process; IEA:Compara. |
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SMART | |
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PRINTS | |