CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006541
UniProt Accession
Genbank Protein ID
 M86377 
Genbank Nucleotide ID
Protein Name
 Dual specificity protein kinase TTK 
Protein Synonyms/Alias
 ESK; PYT 
Gene Name
 Ttk 
Gene Synonyms/Alias
 Esk 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
851SSSKTFDKKRERK**acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (By similarity). Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. May play some role in the control of cell proliferation or differentiation and could be involved in modulating different levels of signal transduction pathways. 
Sequence Annotation
 DOMAIN 524 790 Protein kinase.
 NP_BIND 530 538 ATP (By similarity).
 ACT_SITE 646 646 Proton acceptor (By similarity).
 BINDING 552 552 ATP (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 32 32 Phosphothreonine (By similarity).
 MOD_RES 36 36 Phosphoserine (By similarity).
 MOD_RES 277 277 Phosphoserine (By similarity).
 MOD_RES 342 342 Phosphoserine (By similarity).
 MOD_RES 428 428 Phosphothreonine.
 MOD_RES 435 435 Phosphoserine (By similarity).
 MOD_RES 820 820 Phosphoserine (By similarity).  
Keyword
 Acetylation; Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 856 AA 
Protein Sequence
MEAEELIGSS VTIDSIMSKM RDIKNKINED CTDELSLSKI CADHTETVNQ IMRVGNTPEN 60
WLNFLLKLEK NSSPLNDDLL NKLIGRYSQA IEVLPPDKYG QNESFARIQV RLAELKAIQE 120
PDDARDYFQM ARENCKKFAF VHVSFAQFEL SQGNLKKSEQ LLHKAVETGA VPLQMLETAM 180
RNLHLQKKQL LPEEDKKSVS ASTVLSAQEP FSSSLGNVQN RSISCESRGQ AGAARVLYGE 240
NLPPQDAEVR HQNPFKQTHA AKRSCPFGRV PVNLLNSPDF YVKTDSSAVT QLTTRLALSS 300
VPLPYVTCLL HLQLLALAGL AKGSGPDRDA ILPGSRPRGS DSYELRGLKP IQTIYLKDSL 360
VSNEKSSELM SDLIALKSKT DSSLTKLEET KPEIAERRPM QWQSTRKPEC VFQNPAAFAP 420
LRHVPDVTPK ADKESPPISV PKWLDPKSAC ETPSSSSLDD YMKCFKTPVV KNDFPPACPS 480
STPYSQLARL QQQQQQGLST PLQSLQISGS SSINECISVN GRIYSILKQI GSGGSSKVFQ 540
VLNEKKQINA IKYVNLEDAD SQTIESYRNE IAFLNKLQQH SDKIIRLYDY EITEQYIYMV 600
MECGNIDLNS WLKKKKSINP WERKSYWKNM LEAVHIIHQH GIVHSDLKPA NFVIVDGMLK 660
LIDFGIANQM QPDTTSIVKD SQVGTVNYMA PEAIRDMSSS RENSKIRTKV SPRSDVWSLG 720
CILYYMTYGR TPFQHIINQV SKLHAIINPA HEIEFPEISE KDLRDVLKCC LVRNPKERIS 780
IPELLTHPYV QIQPHPGSQM ARGATDEMKY VLGQLVGLNS PNSILKTAKT LYERYNCGEG 840
QDSSSSKTFD KKRERK 856 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.
 GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR027084; Dual_sp_prot_kinse_Ttk.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS.
 IPR011990; TPR-like_helical. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS