CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004235
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heat shock protein beta-1 
Protein Synonyms/Alias
 HspB1; Growth-related 25 kDa protein; Heat shock 25 kDa protein; HSP 25; Heat shock 27 kDa protein; HSP 27; p25 
Gene Name
 Hspb1 
Gene Synonyms/Alias
 Hsp25; Hsp27 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
116APEELTVKTKEGVVEubiquitination[1]
118EELTVKTKEGVVEITubiquitination[1]
145ISRCFTRKYTLPPGVubiquitination[1]
202IGGPEAGKSEQSGAKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Involved in stress resistance and actin organization. 
Sequence Annotation
 REGION 74 209 Interaction with TGFB1I1 (By similarity).
 MOD_RES 15 15 Phosphoserine; by MAPKAPK2, MAPKAPK3, PKA
 MOD_RES 27 27 Phosphoserine (By similarity).
 MOD_RES 86 86 Phosphoserine; by MAPKAPK2, MAPKAPK3,
 MOD_RES 87 87 Phosphoserine (By similarity).
 MOD_RES 90 90 Phosphoserine (By similarity).
 MOD_RES 127 127 N6-acetyllysine (By similarity).
 MOD_RES 203 203 Phosphoserine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 209 AA 
Protein Sequence
MTERRVPFSL LRSPSWEPFR DWYPAHSRLF DQAFGVPRLP DEWSQWFSAA GWPGYVRPLP 60
AATAEGPAAV TLAAPAFSRA LNRQLSSGVS EIRQTADRWR VSLDVNHFAP EELTVKTKEG 120
VVEITGKHEE RQDEHGYISR CFTRKYTLPP GVDPTLVSSS LSPEGTLTVE APLPKAVTQS 180
AEITIPVTFE ARAQIGGPEA GKSEQSGAK 209 
Gene Ontology
 GO:0009986; C:cell surface; ISS:BHF-UCL.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0000502; C:proteasome complex; ISS:BHF-UCL.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0005080; F:protein kinase C binding; IDA:BHF-UCL.
 GO:0008426; F:protein kinase C inhibitor activity; IDA:BHF-UCL.
 GO:0043130; F:ubiquitin binding; ISS:BHF-UCL.
 GO:0007243; P:intracellular protein kinase cascade; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IDA:BHF-UCL.
 GO:0045766; P:positive regulation of angiogenesis; IEA:Compara.
 GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IEA:Compara.
 GO:0038033; P:positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; IEA:Compara.
 GO:0032731; P:positive regulation of interleukin-1 beta production; IDA:BHF-UCL.
 GO:0042535; P:positive regulation of tumor necrosis factor biosynthetic process; IDA:BHF-UCL.
 GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB cascade; IDA:BHF-UCL.
 GO:0006986; P:response to unfolded protein; NAS:BHF-UCL.
 GO:0009615; P:response to virus; ISS:BHF-UCL. 
Interpro
 IPR002068; a-crystallin/Hsp20_dom.
 IPR001436; Alpha-crystallin/HSP.
 IPR008978; HSP20-like_chaperone. 
Pfam
 PF00011; HSP20 
SMART
  
PROSITE
 PS01031; HSP20 
PRINTS
 PR00299; ACRYSTALLIN.