UniProt Accession

 H2A1J_HUMAN; Q99878; A2RUU6; Q5JXQ5 

Genbank Protein ID

 Z83736; AY131990; AL049822; CH471081; BC066232; BC066233; BC066234; BC066235; BC066236; BC066237; BC133048; BC133050 

Genbank Nucleotide ID

 CAB06031.1; AAN59971.1; CAB81656.1; EAX03109.1; AAH66232.1; AAH66233.1; AAH66234.1; AAH66235.1; AAH66236.1; AAH66237.1; AAI33049.1; AAI33051.1 

Protein Name

 Histone H2A type 1-J 

Protein Synonyms/Alias

 Histone H2A/e 

Gene Name

 HIST1H2AJ 

Gene Synonyms/Alias

 H2AFE 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
96	RNDEELNKLLGKVTI	ubiquitination	[1]
100	ELNKLLGKVTIAQGG	ubiquitination	[1]
119	IQAVLLPKKTESHHK	ubiquitination	[1]
120	QAVLLPKKTESHHKT	ubiquitination	[1]
126	KKTESHHKTK*****	ubiquitination	[1, 2]
128	TESHHKTK*******	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine; by RPS6KA5.
 MOD_RES 4 4 Citrulline.
 MOD_RES 6 6 N6-acetyllysine.
 MOD_RES 37 37 N6-crotonyl-L-lysine.
 MOD_RES 119 119 N6-crotonyl-L-lysine.
 MOD_RES 120 120 N6-crotonyl-L-lysine; alternate.
 MOD_RES 121 121 Phosphothreonine (Probable).
 MOD_RES 126 126 N6-crotonyl-L-lysine.
 CROSSLNK 14 14 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 16 16 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 120 120 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Chromosome; Citrullination; Complete proteome; DNA-binding; Isopeptide bond; Methylation; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 128 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; NAS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; NAS:UniProtKB.
 GO:0006334; P:nucleosome assembly; NAS:UniProtKB. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR002119; Histone_H2A. 

Pfam

 PF00125; Histone 

SMART

 SM00414; H2A 

PROSITE

 PS00046; HISTONE_H2A 

PRINTS

 PR00620; HISTONEH2A.