UniProt Accession

 TPM1_RABIT; P58772; P02558; P46902; P99034 

Genbank Protein ID

 S78854; V00892 

Genbank Nucleotide ID

 AAB34957.1; CAA24257.1 

Protein Name

 Tropomyosin alpha-1 chain 

Protein Synonyms/Alias

 Alpha-tropomyosin; Tropomyosin-1 

Gene Name

 TPM1 

Gene Synonyms/Alias

 TPMA 

Created Date

 July 27, 2013 

Organism

 Oryctolagus cuniculus (Rabbit) 

NCBI Taxa ID

 9986 

Lysine Modification

Position	Peptide	Type	References
5	***MDAIKKKMQMLK	acetylation	[1]
6	**MDAIKKKMQMLKL	acetylation	[1]
7	*MDAIKKKMQMLKLD	acetylation	[1]
12	KKKMQMLKLDKENAL	acetylation	[1]
15	MQMLKLDKENALDRA	acetylation	[1]
48	DELVSLQKKLKGTED	acetylation	[1]
65	DKYSEALKDAQEKLE	acetylation	[1]
70	ALKDAQEKLELAEKK	acetylation	[1]
118	QKLEEAEKAADESER	acetylation	[1]
128	DESERGMKVIESRAQ	acetylation	[1]
149	EIQEIQLKEAKHIAE	acetylation	[1]
152	EIQLKEAKHIAEDAD	acetylation	[1]
168	KYEEVARKLVIIESD	acetylation	[1]
213	SLEAQAEKYSQKEDK	acetylation	[1]
231	EIKVLSDKLKEAETR	acetylation	[1]
233	KVLSDKLKEAETRAE	acetylation	[1]
248	FAERSVTKLEKSIDD	acetylation	[1]
251	RSVTKLEKSIDDLED	acetylation	[1]
266	ELYAQKLKYKAISEE	acetylation	[1]

Reference

 [1] Polymerizability of rabbit skeletal tropomyosin: effects of enzymic and chemical modifications.
 Johnson P, Smillie LB.
 Biochemistry. 1977 May 17;16(10):2264-9. [PMID: 861209] 

Functional Description

 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 283 283 Phosphoserine; by DAPK1.
 CROSSLNK 77 77 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Acetylation; Actin-binding; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Isopeptide bond; Muscle protein; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 284 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. 

Interpro

 IPR000533; Tropomyosin. 

Pfam

 PF00261; Tropomyosin 

SMART

  

PROSITE

 PS00326; TROPOMYOSIN 

PRINTS

 PR00194; TROPOMYOSIN.