UniProt Accession

 CNTP2_HUMAN; Q9UHC6; D3DWG2; Q14DG2; Q52LV1; Q5H9Q7; Q9UQ12 

Genbank Protein ID

 AF193613; AF319045; AF318292; AF318298; AB020675; CR933671; CH471146; BC093780; BC113373 

Genbank Nucleotide ID

 AAF25199.1; AAK34932.1; AAK49902.1; AAK49903.1; BAA74891.1; CAI45967.1; EAW80084.1; AAH93780.1; AAI13374.1 

Protein Name

 Contactin-associated protein-like 2 

Protein Synonyms/Alias

 Cell recognition molecule Caspr2 

Gene Name

 CNTNAP2 

Gene Synonyms/Alias

 CASPR2; KIAA0868 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
1326	TETIDESKKEWLI**	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction. 

Sequence Annotation

 DOMAIN 35 181 F5/8 type C.
 DOMAIN 216 368 Laminin G-like 1.
 DOMAIN 401 552 Laminin G-like 2.
 DOMAIN 554 591 EGF-like 1.
 DOMAIN 592 798 Fibrinogen C-terminal.
 DOMAIN 799 963 Laminin G-like 3.
 DOMAIN 963 1002 EGF-like 2.
 DOMAIN 1055 1214 Laminin G-like 4.
 MOD_RES 589 589 Phosphothreonine.
 MOD_RES 595 595 Phosphotyrosine.
 CARBOHYD 289 289 N-linked (GlcNAc...) (Potential).
 CARBOHYD 346 346 N-linked (GlcNAc...) (Potential).
 CARBOHYD 363 363 N-linked (GlcNAc...) (Potential).
 CARBOHYD 379 379 N-linked (GlcNAc...) (Potential).
 CARBOHYD 436 436 N-linked (GlcNAc...) (Potential).
 CARBOHYD 506 506 N-linked (GlcNAc...) (Potential).
 CARBOHYD 507 507 N-linked (GlcNAc...) (Potential).
 CARBOHYD 546 546 N-linked (GlcNAc...) (Potential).
 CARBOHYD 630 630 N-linked (GlcNAc...) (Potential).
 CARBOHYD 735 735 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1116 1116 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1198 1198 N-linked (GlcNAc...) (Potential).
 DISULFID 35 181 By similarity.
 DISULFID 336 368 By similarity.
 DISULFID 520 552 By similarity.
 DISULFID 558 569 By similarity.
 DISULFID 563 578 By similarity.
 DISULFID 580 590 By similarity.
 DISULFID 936 963 By similarity.
 DISULFID 967 980 By similarity.
 DISULFID 974 989 By similarity.
 DISULFID 991 1001 By similarity.
 DISULFID 1178 1214 By similarity.  

Keyword

 Alternative splicing; Cell adhesion; Chromosomal rearrangement; Complete proteome; Disulfide bond; EGF-like domain; Epilepsy; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1331 AA 

Protein Sequence

Gene Ontology

 GO:0030673; C:axolemma; IDA:BHF-UCL.
 GO:0009986; C:cell surface; IDA:BHF-UCL.
 GO:0030425; C:dendrite; ISS:BHF-UCL.
 GO:0005769; C:early endosome; IDA:BHF-UCL.
 GO:0005794; C:Golgi apparatus; IDA:BHF-UCL.
 GO:0044224; C:juxtaparanode region of axon; ISS:BHF-UCL.
 GO:0043204; C:perikaryon; ISS:BHF-UCL.
 GO:0008076; C:voltage-gated potassium channel complex; IDA:BHF-UCL.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0034613; P:cellular protein localization; ISS:BHF-UCL.
 GO:0045163; P:clustering of voltage-gated potassium channels; ISS:BHF-UCL.
 GO:0021761; P:limbic system development; IEP:BHF-UCL.
 GO:0031175; P:neuron projection development; IEA:Compara.
 GO:0008038; P:neuron recognition; NAS:UniProtKB.
 GO:0071205; P:protein localization to juxtaparanode region of axon; IEA:Compara.
 GO:0021756; P:striatum development; IEP:BHF-UCL.
 GO:0071109; P:superior temporal gyrus development; IEP:BHF-UCL.
 GO:0021794; P:thalamus development; IEP:BHF-UCL.
 GO:0019226; P:transmission of nerve impulse; NAS:UniProtKB.
 GO:0071625; P:vocalization behavior; IMP:BHF-UCL. 

Interpro

 IPR000421; Coagulation_fac_5/8-C_type_dom.
 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR000742; EG-like_dom.
 IPR002181; Fibrinogen_a/b/g_C_dom.
 IPR008979; Galactose-bd-like.
 IPR001791; Laminin_G.
 IPR003585; Neurexin-like. 

Pfam

 PF00008; EGF
 PF00754; F5_F8_type_C
 PF02210; Laminin_G_2 

SMART

 SM00294; 4.1m
 SM00181; EGF
 SM00231; FA58C
 SM00282; LamG 

PROSITE

 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01285; FA58C_1
 PS01286; FA58C_2
 PS50022; FA58C_3
 PS00514; FIBRINOGEN_C_1
 PS51406; FIBRINOGEN_C_2
 PS50025; LAM_G_DOMAIN 

PRINTS