UniProt Accession

 B4DDV6_HUMAN; B4DDV6 

Genbank Protein ID

 AC078846; AC084864; AK293351 

Genbank Nucleotide ID

 BAG56867.1 

Protein Name

 Nuclear factor erythroid 2-related factor 1 

Protein Synonyms/Alias

 cDNA FLJ57098, highly similar to Nuclear respiratory factor 1 

Gene Name

 NRF1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
53	AFIPEMLKYSTGRGK	ubiquitination	[1, 2]
106	QALRTIVKNCYKQHG	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 342 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0007005; P:mitochondrion organization; IEA:Compara.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0051602; P:response to electrical stimulus; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0051593; P:response to folic acid; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara. 

Interpro

 IPR019526; Nrf1_activation-bd.
 IPR019525; Nrf1_NLS/DNA-bd_dimer. 

Pfam

 PF10492; Nrf1_activ_bdg
 PF10491; Nrf1_DNA-bind 

SMART

  

PROSITE

  

PRINTS