UniProt Accession

 UXS5_ARATH; Q9SN95 

Genbank Protein ID

 AL133298; CP002686; CP002686; AY072098; AY096586; AK228600; AK317497; AY087118 

Genbank Nucleotide ID

 CAB62035.1; AEE78158.1; AEE78159.1; AAL59920.1; AAM20236.1; BAF00515.1; BAH20162.1; AAM64676.1 

Protein Name

 UDP-glucuronic acid decarboxylase 5 

Protein Synonyms/Alias

 UDP-XYL synthase 5; UDP-glucuronate decarboxylase 5; UGD; UXS-5 

Gene Name

 UXS5 

Gene Synonyms/Alias

 At3g46440; F18L15.160 

Created Date

 July 27, 2013 

Organism

 Arabidopsis thaliana (Mouse-ear cress) 

NCBI Taxa ID

 3702 

Lysine Modification

Position	Peptide	Type	References
6	**MASSDKQTSPKPP	acetylation	[1]

Reference

 [1] Proteins of diverse function and subcellular location are lysine acetylated in Arabidopsis.
 Finkemeier I, Laxa M, Miguet L, Howden AJ, Sweetlove LJ.
 Plant Physiol. 2011 Apr;155(4):1779-90. [PMID: 21311031] 

Functional Description

 Catalyzes the NAD-dependent decarboxylation of UDP- glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity). 

Sequence Annotation

 NP_BIND 60 85 NAD (By similarity).
 NP_BIND 172 176 NAD (By similarity).
 NP_BIND 214 218 Substrate (By similarity).
 NP_BIND 231 238 Substrate (By similarity).
 NP_BIND 298 302 Substrate (By similarity).
 ACT_SITE 172 172 Proton acceptor (By similarity).
 BINDING 169 169 Substrate (By similarity).
 BINDING 201 201 Substrate (By similarity).
 BINDING 213 213 NAD (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Decarboxylase; Lyase; NAD; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 341 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:TAIR.
 GO:0050662; F:coenzyme binding; IEA:InterPro.
 GO:0048040; F:UDP-glucuronate decarboxylase activity; IEA:EC.
 GO:0042732; P:D-xylose metabolic process; TAS:TAIR.
 GO:0033320; P:UDP-D-xylose biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR001509; Epimerase_deHydtase.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF01370; Epimerase 

SMART

  

PROSITE

  

PRINTS