| Tag | Content |
|---|
| CPLM ID | CPLM-014343 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
Protein Synonyms/Alias | Cam-PDE 1A; 61 kDa Cam-PDE |
Gene Name | Pde1a |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 46 | LIGEQTEKMWQRLKG | ubiquitination | [1] | | 518 | SLSAVDLKSFKNNLV | ubiquitination | [1] | | 532 | VDIIQQNKERWKELA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP (By similarity). |
Sequence Annotation | REGION 44 64 Calmodulin-binding.
REGION 213 535 Catalytic (By similarity).
ACT_SITE 239 239 Proton donor (By similarity).
METAL 243 243 Divalent metal cation 1 (By similarity).
METAL 279 279 Divalent metal cation 1 (By similarity).
METAL 280 280 Divalent metal cation 1 (By similarity).
METAL 280 280 Divalent metal cation 2 (By similarity).
METAL 386 386 Divalent metal cation 1 (By similarity). |
Keyword | Alternative splicing; Calmodulin-binding; cAMP; cGMP; Complete proteome; Hydrolase; Metal-binding; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 565 AA |
Protein Sequence | MCDSSPSSSH VWIAPVRNII MGSTDTDIEE LENATYKYLI GEQTEKMWQR LKGILRCLVK 60
QLEKGDVNVV DLKKNIEYAA SVLEAVYIDE TRRLLDTEDE LSDIQTDSVP SEVRDWLAST 120
FTRKMGMMKK KPEEKPKFRS IVHAVQAGIF VERMYRKNYH MVGLTYPAAV IVTLKEVDKW 180
SFDVFALNEA SGEHSLKFMI YELFTRYDLI NRFKIPVSCL IAFAEALEVG YSKHKNPYHN 240
LVHAADVTQT VHYIMLHTGI MHWLTELEIL AMVFAAAIHD YEHTGTTNNF HIQTRSDVAI 300
LYNDRSVLEN HHVSAAYRLM QEEEMNILVN LSKDDWRDLR NLVIEMVLAT DMSGHFQQIK 360
NIRNSLQQPE GIDRAKTMSL ILHAADISHP AKTWKLHYRW TMALMEEFFL QGDKEAELGL 420
PFSPLCDRKS TMVAQSQIGF IDFIVEPTFS LLTDSTEKIV IPLIEEASKS QSSNYGASSS 480
STMIGFHVAD SLRRSNTKGS VCDGSYAPDY SLSAVDLKSF KNNLVDIIQQ NKERWKELAA 540
QGELDLHKNS EELGNTEEKH ADTRP 565 |
Gene Ontology | GO:0048101; F:calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; ISO:MGI. GO:0004117; F:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; ISO:MGI. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0007165; P:signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |