CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007996
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium- and chloride-dependent glycine transporter 1 
Protein Synonyms/Alias
 GlyT-1; GlyT1; Solute carrier family 6 member 9 
Gene Name
 SLC6A9 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
20AVPSEATKRDQNLKRubiquitination[1]
614VQPLHPDKAQIPIVGubiquitination[1, 2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission. 
Sequence Annotation
  
Keyword
 Alternative splicing; Amino-acid transport; Complete proteome; Membrane; Neurotransmitter transport; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 706 AA 
Protein Sequence
MVGKGAKGML NGAVPSEATK RDQNLKRGNW GNQIEFVLTS VGYAVGLGNV WRFPYLCYRN 60
GGGAFMFPYF IMLIFCGIPL FFMELSFGQF ASQGCLGVWR ISPMFKGVGY GMMVVSTYIG 120
IYYNVVICIA FYYFFSSMTH VLPWAYCNNP WNTHDCAGVL DASNLTNGSR PAALPSNLSH 180
LLNHSLQRTS PSEEYWRLYV LKLSDDIGNF GEVRLPLLGC LGVSWLVVFL CLIRGVKSSG 240
KVVYFTATFP YVVLTILFVR GVTLEGAFDG IMYYLTPQWD KILEAKVWGD AASQIFYSLG 300
CAWGGLITMA SYNKFHNNCY RDSVIISITN CATSVYAGFV IFSILGFMAN HLGVDVSRVA 360
DHGPGLAFVA YPEALTLLPI SPLWSLLFFF MLILLGLGTQ FCLLETLVTA IVDEVGNEWI 420
LQKKTYVTLG VAVAGFLLGI PLTSQAGIYW LLLMDNYAAS FSLVVISCIM CVAIMYIYGH 480
RNYFQDIQMM LGFPPPLFFQ ICWRFVSPAI IFFILVFTVI QYQPITYNHY QYPGWAVAIG 540
FLMALSSVLC IPLYAMFRLC RTDGDTLLQR LKNATKPSRD WGPALLEHRT GRYAPTIAPS 600
PEDGFEVQPL HPDKAQIPIV GSNGSSRLQD SRI 633 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0015375; F:glycine:sodium symporter activity; TAS:ProtInc.
 GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro. 
Interpro
 IPR000175; Na/ntran_symport.
 IPR003028; Na/ntran_symport_glycine_GLY1. 
Pfam
 PF00209; SNF 
SMART
  
PROSITE
 PS00610; NA_NEUROTRAN_SYMP_1
 PS00754; NA_NEUROTRAN_SYMP_2
 PS50267; NA_NEUROTRAN_SYMP_3 
PRINTS
 PR01204; GLY1TRNSPORT.
 PR00176; NANEUSMPORT.