UniProt Accession

 APH1A_HUMAN; Q96BI3; B4DQK0; Q5TB22; Q5TB23; Q969R6; Q9BVG0; Q9Y386 

Genbank Protein ID

 AF508787; AY113698; AY113699; AF151835; AY358951; AK027879; AK075295; AK298832; AL138795; AL138795; CH471121; CH471121; CH471121; BC001230; BC008732; BC009501; BC015568; BC017699; BC020590 

Genbank Nucleotide ID

 AAN63816.1; AAM61955.1; AAM61956.1; AAD34072.1; AAQ89310.1; BAG51389.1; BAC11529.1; BAG60962.1; CAI22811.1; CAI22812.1; EAW53565.1; EAW53566.1; EAW53567.1; AAH01230.1; AAH08732.1; AAH09501.1; AAH15568.1; AAH17699.1; AAH20590.1 

Protein Name

 Gamma-secretase subunit APH-1A 

Protein Synonyms/Alias

 APH-1a; Aph-1alpha; Presenilin-stabilization factor 

Gene Name

 APH1A 

Gene Synonyms/Alias

 PSF; CGI-78; UNQ579/PRO1141 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
96	AYYKLLKKADEGLAS	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Endoplasmic reticulum; Golgi apparatus; Membrane; Notch signaling pathway; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 265 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:HGNC.
 GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; IDA:HGNC.
 GO:0004175; F:endopeptidase activity; IEA:Compara.
 GO:0042987; P:amyloid precursor protein catabolic process; IMP:UniProtKB.
 GO:0097190; P:apoptotic signaling pathway; TAS:Reactome.
 GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
 GO:0031293; P:membrane protein intracellular domain proteolysis; IMP:UniProtKB.
 GO:0001656; P:metanephros development; IEA:Compara.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0007220; P:Notch receptor processing; IMP:UniProtKB.
 GO:0007219; P:Notch signaling pathway; TAS:Reactome.
 GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
 GO:0016485; P:protein processing; IDA:HGNC. 

Interpro

 IPR009294; Aph-1. 

Pfam

 PF06105; Aph-1 

SMART

  

PROSITE

  

PRINTS