| Tag | Content |
|---|
| CPLM ID | CPLM-021695 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | O-phosphoseryl-tRNA(Sec) selenium transferase |
Protein Synonyms/Alias | Liver-pancreas antigen; LP; SLA-p35; SLA/LP autoantigen; Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; Soluble liver antigen; SLA; UGA suppressor tRNA-associated protein; tRNA(Ser/Sec)-associated antigenic protein |
Gene Name | SEPSECS |
Gene Synonyms/Alias | TRNP48 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 173 | IWPRIDQKSCFKSMI | ubiquitination | [1] | | 203 | DELRTDLKAVEAKVQ | ubiquitination | [1] | | 208 | DLKAVEAKVQELGPD | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. |
Sequence Annotation | REGION 1 44 Tetramerization.
REGION 96 106 Phosphate loop (P-loop).
REGION 474 493 SLA/LP epitope.
BINDING 75 75 PLP (By similarity).
BINDING 97 97 Substrate.
BINDING 98 98 Substrate.
BINDING 105 105 Substrate.
BINDING 271 271 tRNA variable arm.
BINDING 313 313 Substrate.
BINDING 398 398 tRNA discriminator base.
BINDING 463 463 tRNA acceptor arm.
MOD_RES 284 284 N6-(pyridoxal phosphate)lysine. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Protein biosynthesis; Pyridoxal phosphate; Reference proteome; RNA-binding; Selenium; Transferase; tRNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 501 AA |
Protein Sequence | MNRESFAAGE RLVSPAYVRQ GCEARRSHEH LIRLLLEKGK CPENGWDEST LELFLHELAI 60
MDSNNFLGNC GVGEREGRVA SALVARRHYR FIHGIGRSGD ISAVQPKAAG SSLLNKITNS 120
LVLDIIKLAG VHTVANCFVV PMATGMSLTL CFLTLRHKRP KAKYIIWPRI DQKSCFKSMI 180
TAGFEPVVIE NVLEGDELRT DLKAVEAKVQ ELGPDCILCI HSTTSCFAPR VPDRLEELAV 240
ICANYDIPHI VNNAYGVQSS KCMHLIQQGA RVGRIDAFVQ SLDKNFMVPV GGAIIAGFND 300
SFIQEISKMY PGRASASPSL DVLITLLSLG SNGYKKLLKE RKEMFSYLSN QIKKLSEAYN 360
ERLLHTPHNP ISLAMTLKTL DEHRDKAVTQ LGSMLFTRQV SGARVVPLGS MQTVSGYTFR 420
GFMSHTNNYP CAYLNAASAI GMKMQDVDLF IKRLDRCLKA VRKERSKESD DNYDKTEDVD 480
IEEMALKLDN VLLDTYQDAS S 501 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:HGNC. GO:0005634; C:nucleus; ISS:HGNC. GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. GO:0016785; F:transferase activity, transferring selenium-containing groups; IEA:InterPro. GO:0000049; F:tRNA binding; ISS:HGNC. GO:0001514; P:selenocysteine incorporation; ISS:HGNC. GO:0097056; P:selenocysteinyl-tRNA(Sec) biosynthetic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |