CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006335
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 tRNA 2-selenouridine synthase 
Protein Synonyms/Alias
 Selenophosphate-dependent tRNA 2-selenouridine synthase 
Gene Name
 selU 
Gene Synonyms/Alias
 ybbB; b0503; JW0491 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
69AALALGHKLVAGEIRacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA. 
Sequence Annotation
 DOMAIN 14 137 Rhodanese.
 ACT_SITE 97 97 S-selanylcysteine intermediate  
Keyword
 Complete proteome; Reference proteome; Selenium; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 364 AA 
Protein Sequence
MQERHTEQDY RALLIADTPI IDVRAPIEFE HGAMPAAINL PLMNNDERAA VGTCYKQQGS 60
DAALALGHKL VAGEIRQQRM DAWRAACLQN PQGILCCARG GQRSHIVQSW LHAAGIDYPL 120
VEGGYKALRQ TAIQATIELA QKPIVLIGGC TGSGKTLLVQ QQPNGVDLEG LARHRGSAFG 180
RTLQPQLSQA SFENLLAAEM LKTDARQNLR LWVLEDESRM IGSNHLPECL RERMTQAAIA 240
VVEDPFEIRL ERLNEEYFLR MHHDFTHAYG DEQGWQEYCE YLHHGLSAIK RRLGLQRYNE 300
LAARLDAALT TQLTTGSTDG HLAWLVPLLE EYYDPMYRYQ LEKKAEKVVF RGEWAEVAEW 360
VKAR 364 
Gene Ontology
 GO:0043828; F:tRNA 2-selenouridine synthase activity; IDA:EcoCyc.
 GO:0070329; P:tRNA seleno-modification; IEA:InterPro.
 GO:0002098; P:tRNA wobble uridine modification; IMP:EcoCyc. 
Interpro
 IPR001763; Rhodanese-like_dom.
 IPR017582; tRNA_2-selenouridine_synthase. 
Pfam
 PF00581; Rhodanese 
SMART
 SM00450; RHOD 
PROSITE
 PS50206; RHODANESE_3 
PRINTS