| Tag | Content |
|---|
| CPLM ID | CPLM-019850 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein kinase C and casein kinase II substrate protein 3 |
Protein Synonyms/Alias | |
Gene Name | Pacsin3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 175 | QTRESHAKADSSMSQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity. |
Sequence Annotation | DOMAIN 10 73 FCH.
DOMAIN 363 424 SH3.
REGION 1 304 F-BAR domain.
MOD_RES 276 276 Phosphoserine.
MOD_RES 319 319 Phosphoserine.
MOD_RES 324 324 Phosphothreonine (By similarity).
MOD_RES 327 327 Phosphoserine (By similarity).
MOD_RES 354 354 Phosphoserine.
MOD_RES 383 383 Phosphoserine (By similarity). |
Keyword | 3D-structure; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Endocytosis; Lipid-binding; Membrane; Phosphoprotein; Reference proteome; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 424 AA |
Protein Sequence | MAPEEDAGGE VLGGSFWEAG NYRRTVQRVE DGHRLCGDLV SCFQERARIE KAYAQQLADW 60
ARKWRGAVEK GPQYGTLEKA WHAFFTAAER LSELHLEVRE KLHGPDSERV RTWQRGAFHR 120
PVLGGFRESR AAEDGFRKAQ KPWLKRLKEV EASKKSYHTA RKDEKTAQTR ESHAKADSSM 180
SQEQLRKLQE RVGRCTKEAE KMKTQYEQTL AELNRYTPRY MEDMEQAFES CQAAERQRLL 240
FFKDVLLTLH QHLDLSSSDK FHELHRDLQQ SIEAASDEED LRWWRSTHGP GMAMNWPQFE 300
EWSLDTQRAI SRKEKGGRSP DEVTLTSIVP TRDGTAPPPQ SPSSPGSGQD EDWSDEESPR 360
KVATGVRVRA LYDYAGQEAD ELSFRAGEEL LKMSEEDEQG WCQGQLQSGR IGLYPANYVE 420
CVGA 424 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:MGI. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0019855; F:calcium channel inhibitor activity; IMP:UniProtKB. GO:0008092; F:cytoskeletal protein binding; IDA:MGI. GO:0008289; F:lipid binding; IDA:UniProtKB. GO:0006897; P:endocytosis; IEA:UniProtKB-KW. GO:0097320; P:membrane tubulation; IDA:UniProtKB. GO:0051926; P:negative regulation of calcium ion transport; IMP:UniProtKB. GO:0045806; P:negative regulation of endocytosis; IMP:UniProtKB. GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |