CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034706
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ras GTPase-activating protein SynGAP 
Protein Synonyms/Alias
  
Gene Name
 Syngap1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
55RKSVPGGKQYSMEAAacetylation[1]
651LSKEALLKLGPLPRLacetylation[1]
732ARLPSPTKEKPPPPPubiquitination[2]
734LPSPTKEKPPPPPPGubiquitination[2]
780QKMLSVNKSVSMLDLubiquitination[2]
1071GGGGGGLKPSITKQHubiquitination[2]
1137ESRLDRVKEYEEEIHubiquitination[2]
1173SQEEQTSKILMQYQAubiquitination[2]
1201VEKDSQIKSIIGRLMubiquitination[2]
1229AEPLPEPKKRLLDAQubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTPase activation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1249 AA 
Protein Sequence
MGLRPPTPTP SGGSGSGSLP PPSHRQPLRR RCSSCCFPGE YHLGRSRRKS VPGGKQYSME 60
AAPAAPFRPS QGFLSRRLKS SIKRTKSQPK LDRTSSFRQI LPRFRSADHD RARLMQSFKE 120
SHSHESLLSP SSAAEALELN LDEDSIIKPV HSSILGQEFC FEVTTSSGTK CFACRSAAER 180
DKWIENLQRA VKPNKDNSRR VDNVLKLWII EARELPPKKR YYCELCLDDM LYARTTSKPR 240
SASGDTVFWG EHFEFNNLPA VRALRLHLYR DSDKKRKKDK AGYVGLVTVP VATLAGRHFT 300
EQWYPVTLPT GSGGSGGMGS GGGGGSGGGS GGKGKGGCPA VRLKARYQTM SILPMELYKE 360
FAEYVTNHYR MLCAVLEPAL NVKGKEEVAS ALVHILQSTG KAKDFLSDMA MSEVDRFMER 420
EHLIFRENTL ATKAIEEYMR LIGQKYLKDA IGEFIRALYE SEENCEVDPI KCTASSLAEH 480
QANLRMCCEL ALCKVVNSHC VFPGELKEVF ASWRLRCAER GREDIADRLI SASLFLRFLC 540
PAIMSPSLFG LMQEYPDEQT SRTLTLIAKV IQNLANFSKF TSKEDFLGFM NEFLELEWGS 600
MQQFLYEISN LDTLTNSSSF EGYIDLGREL STLHALLWEV LPQLSKEALL KLGPLPRLLS 660
DISTALRNPN IQRQPSRQSE RARSQPMVLR GPSAEMQGYM MRDLNSSIDL QSFMARGLNS 720
SMDMARLPSP TKEKPPPPPP GGGKDLFYVS RPPLARSSPA YCTSSSDITE PEQKMLSVNK 780
SVSMLDLQGD GPGGRLNSSS VSNLAAVGDL LHSSQASLTA ALGLRPAPAG RLSQGSGSSI 840
TAAGMRLSQM GVTTDGVPAQ QLRIPLSFQN PLFHMAADGP GPPAGHGGSS GHGPPSSHHH 900
HHHHHHHRGG EPPGDTFAPF HGYSKSEDLS TGVPKPPAAS ILHSHSYSDE FGPSGTDFTR 960
RQLSLQDNLQ HMLSPPQITI GPQRPAPSGP GGGSGGGSGG GGGGQPPPLQ RGKSQQLTVS 1020
AAQKPRPSSG NLLQSPEPSY GPARPRQQSL SKEGSIGGSG GSGGGGGGGL KPSITKQHSQ 1080
TPSTLNPTMP ASERTVAWVS NMPHLSADIE SAHIEREEYK LKEYSKSMDE SRLDRVKEYE 1140
EEIHSLKERL HMSNRKLEEY ERRLLSQEEQ TSKILMQYQA RLEQSEKRLR QQQVEKDSQI 1200
KSIIGRLMLV EEELRRDHPA MAEPLPEPKK RLLDAQRGSF PPWVQQTRV 1249 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR021887; DUF3498.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR001936; RasGAP.
 IPR023152; RasGAP_CS.
 IPR008936; Rho_GTPase_activation_prot.
 IPR023315; SynGAP_C2_N. 
Pfam
 PF00168; C2
 PF12004; DUF3498
 PF00616; RasGAP 
SMART
 SM00239; C2
 SM00233; PH
 SM00323; RasGAP 
PROSITE
 PS50003; PH_DOMAIN
 PS00509; RAS_GTPASE_ACTIV_1
 PS50018; RAS_GTPASE_ACTIV_2 
PRINTS