UniProt Accession

 TPM4_RAT; P09495 

Genbank Protein ID

 J02780; Y00169 

Genbank Nucleotide ID

 AAA42291.1; CAA68360.1 

Protein Name

 Tropomyosin alpha-4 chain 

Protein Synonyms/Alias

 Tropomyosin-4; TM-4 

Gene Name

 Tpm4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
11	LNSLEAVKRKIQALQ	acetylation	[1]
44	GERERREKAEGDAAA	acetylation	[1]
92	DESERGMKVIENRAM	acetylation	[1]
100	VIENRAMKDEEKMEI	acetylation	[1]
116	EMQLKEAKHIAEEAD	acetylation	[1]
132	KYEEVARKLVILEGE	acetylation	[1]
153	RAEVSELKSSDLEEE	acetylation	[1]
162	SDLEEELKNVTNNLK	acetylation	[1]
169	KNVTNNLKSLEAASE	acetylation	[1]
177	SLEAASEKYSEKEDK	acetylation	[1]
181	ASEKYSEKEDKYEEE	acetylation	[1]
184	KYSEKEDKYEEEIKL	acetylation	[1]
195	EIKLLSDKLKEAETR	acetylation	[1]
212	FAERTVSKLEKTIDD	acetylation	[1]
223	TIDDLEEKLAQAKEE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 177 177 N6-acetyllysine (By similarity).
 MOD_RES 215 215 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Actin-binding; Calcium; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Metal-binding; Muscle protein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 248 AA 

Protein Sequence

Gene Ontology

 GO:0030863; C:cortical cytoskeleton; IEA:Compara.
 GO:0031941; C:filamentous actin; IEA:Compara.
 GO:0002102; C:podosome; IEA:Compara.
 GO:0001725; C:stress fiber; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006936; P:muscle contraction; TAS:RGD.
 GO:0006979; P:response to oxidative stress; IEA:Compara. 

Interpro

 IPR000533; Tropomyosin. 

Pfam

 PF00261; Tropomyosin 

SMART

  

PROSITE

 PS00326; TROPOMYOSIN 

PRINTS

 PR00194; TROPOMYOSIN.