UniProt Accession

 BCL3_MOUSE; Q9Z2F6 

Genbank Protein ID

 AC149085; AC149282; AF067774 

Genbank Nucleotide ID

 AAC79694.1 

Protein Name

 B-cell lymphoma 3 protein homolog 

Protein Synonyms/Alias

 BCL-3 

Gene Name

 Bcl3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
154	YRILSLFKLGSREVD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit (By similarity). In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation. 

Sequence Annotation

 REPEAT 129 161 ANK 1.
 REPEAT 166 195 ANK 2.
 REPEAT 199 228 ANK 3.
 REPEAT 236 265 ANK 4.
 REPEAT 270 299 ANK 5.
 REPEAT 303 332 ANK 6.
 REPEAT 333 362 ANK 7.
 MOD_RES 396 396 Phosphoserine; by GSK3 (By similarity).
 MOD_RES 400 400 Phosphoserine; by GSK3 (By similarity).  

Keyword

 Activator; ANK repeat; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 448 AA 

Protein Sequence

Gene Ontology

 GO:0032996; C:Bcl3-Bcl10 complex; IEA:Compara.
 GO:0033257; C:Bcl3/NF-kappaB2 complex; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0019730; P:antimicrobial humoral response; IMP:MGI.
 GO:0042742; P:defense response to bacterium; IMP:MGI.
 GO:0042832; P:defense response to protozoan; IMP:MGI.
 GO:0030330; P:DNA damage response, signal transduction by p53 class mediator; IEA:Compara.
 GO:0030198; P:extracellular matrix organization; IMP:MGI.
 GO:0002268; P:follicular dendritic cell differentiation; IMP:MGI.
 GO:0002467; P:germinal center formation; IMP:MGI.
 GO:0002455; P:humoral immune response mediated by circulating immunoglobulin; IMP:MGI.
 GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Compara.
 GO:0002315; P:marginal zone B cell differentiation; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0045415; P:negative regulation of interleukin-8 biosynthetic process; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0042536; P:negative regulation of tumor necrosis factor biosynthetic process; IMP:MGI.
 GO:0032729; P:positive regulation of interferon-gamma production; IMP:MGI.
 GO:0045082; P:positive regulation of interleukin-10 biosynthetic process; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0045727; P:positive regulation of translation; IEA:Compara.
 GO:0000060; P:protein import into nucleus, translocation; IEA:Compara.
 GO:0051101; P:regulation of DNA binding; IEA:Compara.
 GO:0042345; P:regulation of NF-kappaB import into nucleus; IEA:Compara.
 GO:0010225; P:response to UV-C; IEA:Compara.
 GO:0009615; P:response to virus; IEA:Compara.
 GO:0048536; P:spleen development; IMP:MGI.
 GO:0042088; P:T-helper 1 type immune response; IMP:MGI.
 GO:0045064; P:T-helper 2 cell differentiation; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 

Pfam

 PF00023; Ank
 PF12796; Ank_2 

SMART

 SM00248; ANK 

PROSITE

 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 

PRINTS

 PR01415; ANKYRIN.