CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028996
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SUN domain-containing protein 1 
Protein Synonyms/Alias
 Unc-84 homolog A (C. elegans) 
Gene Name
 UNC84A 
Gene Synonyms/Alias
 SUN1; tcag7.1079 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
217LDDDGDLKGGNKAAIubiquitination[1, 2]
253CSMLSERKDVLTAHPubiquitination[1, 3, 4, 5, 6]
321SYESENYKLKTHESKubiquitination[1, 3, 4, 6]
323ESENYKLKTHESKDCubiquitination[1]
529DDPQDVFKPTTSRLKubiquitination[1, 2, 3, 5, 6]
581ELTTLLQKLQARVDQubiquitination[1, 2, 3, 4, 5, 6, 7, 8]
643EKSEAIQKELEQTKQubiquitination[1]
685LSSWRHVKTGCETVDubiquitination[5]
733FSSQFVSKGDLQTMLubiquitination[1, 2, 5]
799LKLYSQDKTGMVDFAubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [7] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [8] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 974 AA 
Protein Sequence
MGDVRKAKEA LAEVQIPPPD AGPSPRCKPP PAERLLGPGR RRRGLRRRRE AVWFEVVNMD 60
FSRLHMYSPP QCVPENTGYT YALSSSYSSD ALDFETEHKL DPVFDSPRMS RRSLRLATTA 120
CTLGDGEAVG ADSGTSSAVS LKNRAARTTK QRRSTNKSAF SINHVSRQVT SSGVSHGGTV 180
SLQDAVTRRP PVLDESWIRE QTTVDHFWGL DDDGDLKGGN KAAIQGNGDV GAAAATAHNG 240
FSCSNCSMLS ERKDVLTAHP AAPGPVSRVY SRDRNQKCGA SFYVNRILWL ARYTASSFSS 300
FLVQLFQVVL MKLSYESENY KLKTHESKDC ESESYKSKSH ESKAHASYYG RMNVREVLRE 360
DGHLSVNGEA LCDDCKGKRH LDAHTAAHSQ SPRLPGRAGT LWHIWACAGY FLLQILRRIG 420
AVGQAVSRTA WSALWLAVVA PGKAASGVFW WLGIGWYQFV TLISWLNVFL LTRCLRNICK 480
FLVLLIPLFL LLAGLSLRGQ GNFFSFLPVL NWASMHRTQR VDDPQDVFKP TTSRLKQPLQ 540
GDSEAFPWHW MSGVEQQVAS LSGQCHHHGE NLRELTTLLQ KLQARVDQME GGAAGPSASV 600
RDAVGQPPRE TDFMAFHQEH EVRMSHLEDI LGKLREKSEA IQKELEQTKQ KTISAVGEQL 660
LPTVEHLQLE LDQLKSELSS WRHVKTGCET VDAVQERVDV QVREMVKLLF SEDQQGGSLE 720
QLLQRFSSQF VSKGDLQTML RDLQLQILRN VTHHVSVTKQ LPTSEAVVSA VSEAGASGIT 780
EAQARAIVNS ALKLYSQDKT GMVDFALESG GGSILSTRCS ETYETKTALM SLFGIPLWYF 840
SQSPRVVIQP DIYPGNCWAF KGSQGYLVVR LSMMIHPAAF TLEHIPKTLS PTGNISSAPK 900
DFAVYGLENE YQEEGQLLGQ FTYDQDGESL QMFQALKRPD DTAFQIVELR IFSNWGHPEY 960
TCLYRFRVHG EPVK 974 
Gene Ontology
 GO:0031965; C:nuclear membrane; IDA:HPA. 
Interpro
 IPR018539; RNA-bd_mt.
 IPR012919; Sad1_UNC_C. 
Pfam
 PF09387; MRP
 PF07738; Sad1_UNC 
SMART
  
PROSITE
 PS51469; SUN 
PRINTS