UniProt Accession

 BARX2_HUMAN; Q9UMQ3; O43518; Q6NT51 

Genbank Protein ID

 AF031924; AF171222; AF171219; AF171220; AF171221; AJ243512; AP003775; CH471065; BC069378; BC111432; BC111572 

Genbank Nucleotide ID

 AAC04705.1; AAF09453.1; AAF09453.1; AAF09453.1; AAF09453.1; CAB50736.1; EAW67743.1; AAH69378.1; AAI11433.1; AAI11573.1 

Protein Name

 Homeobox protein BarH-like 2 

Protein Synonyms/Alias

  

Gene Name

 BARX2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
23	KAARRRYKTFMIDEI	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity). 

Sequence Annotation

 DNA_BIND 133 192 Homeobox.  

Keyword

 Complete proteome; DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 279 AA 

Protein Sequence

Gene Ontology

 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IEA:InterPro.
 GO:0001502; P:cartilage condensation; IEA:Compara.
 GO:0042637; P:catagen; IEA:Compara.
 GO:0014902; P:myotube differentiation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR017970; Homeobox_CS.
 IPR020479; Homeobox_metazoa.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR000047; HTH_motif. 

Pfam

 PF00046; Homeobox 

SMART

 SM00389; HOX 

PROSITE

 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 

PRINTS

 PR00024; HOMEOBOX.
 PR00031; HTHREPRESSR.